Table 1

Clinical characteristics

VariablesEntire cohort
(n=390)
PIIINP at discharge (n=384)P4NP 7S at discharge (n=390)
Low (n=193)High (n=191)P valueLow (n=200)High (n=190)P value
Clinical characteristics
 Age (years)76.2±11.575.2±11.477.5±11.40.04678.8±10.873.4±11.7<0.0001
 Male207 (53)107 (55)95 (50)0.2694 (47)113 (59)0.014
 Hypertension301 (77)143 (74)154 (81)0.13156 (78)145 (76)0.69
 Diabetes mellitus138 (35)65 (34)71 (37)0.563 (32)75 (39)0.11
 Ischaemic heart disease112 (29)54 (28)56 (29)0.7764 (32)48 (29)0.14
 EF<40%154 (39)89 (46)62 (32)0.006174 (37)80 (42)0.3
 Anaemia242 (63)98 (51)143 (75)<0.0001137 (69)105 (56)0.008
Medication at discharge
 β-blocker304 (78)160 (83)138 (73)0.016152 (76)152 (80)0.29
 ACEI or ARB241 (62)128 (66)108 (57)0.049124 (62)117 (62)0.93
 MRA208 (53)101 (52)104 (54)0.6895 (48)113 (59)0.018
 Loop diuretics344 (88)164 (85)174 (91)0.08172 (86)172 (91)0.21
Laboratory tests at discharge
 T-Bil (mg/dL)0.6 (0.5–0.9)0.7 (0.5–1)0.6 (0.4–0.8)0.00010.5 (04–0.7)0.8 (0.6–1.1)<0.0001
 AST (U/L)22 (17–29)23 (18–31)22 (17–28)0.05520 (17–25)25 (19–32)<0.0001
 ALP (U/L)234 (190–303)231 (186–300)238 (194–317)0.098225 (186–288)243 (198–333)0.0094
 γ-GTP (U/L)33 (19–67)37 (22–70)27 (17–63)0.6624 (17–41)52 (26–90)<0.0001
 Albumin (g/dL)3.5 (3.1–3.8)3.5 (3.2–3.9)3.5 (3–3.75)0.133.5 (3.1–3.8)3.5 (3.2–3.8)0.25
 eGFR (mL/min/1.73 m2)47.2±20.253.6±18.640.1±19.2<0.000140 (28–58)48 (34–60)0.031
 BNP (pg/mL)266 (121–480)258 (103–443)268 (131–585)0.2207 (96–397)293 (171–667)<0.0001
 PIIINP (U/mL)0.71 (0.58–0.93)0.58 (0.51–0.64)0.93 (0.81–1.1)<0.00010.67 (0.55–0.86)0.77 (0.61–1)0.0019
 P4NP 7S (ng/mL)5.1 (4.1–6.5)4.7 (3.8–6)5.6 (4.4–7)<0.00014.1 (3.4–4.6)6.6 (5.8–7.6)<0.0001
  • Values are number (%), mean (SD) or median (IQR).

  • ACE-I, angiotensin-converting enzyme inhibitor; ALP, alkaline phosphatase; ARB, angiotensin receptor blocker; AST, aspartate aminotransferase; BNP, brain natriuretic peptide; EF, ejection fraction; eGFR, estimated glomerular filtration rate; γ-GTP, γ-glutamyltransferase; MRA, mineral conrticoid receptor antagonist; PIIINP, N-terminal propeptide of procollagen type III; P4NP 7S, 7S domain of the collagen type IV N-terminal propeptide; T-Bil, total bilirubin.