The prognostic utility of liver function tests, PIIINP and P4NP 7S
| C-index | ΔC-index | P | NRI (95% CI) | P | IDI (95% CI) | P | |
| Reference model | 0.654 (0.579–0.728) | ||||||
| Reference model +T-Bil | 0.668 (0.596–0.741) | 0.014 | 0.43 | 0.207 (–0.037 to 0.452) | 0.096 | 0.0097 (–0.0041 to 0.024) | 0.17 |
| Reference model +AST | 0.653 (0.578–0.729) | –0.001 | 0.97 | –0.0325 (–0.251 to 0.186) | 0.77 | 0.0068 (–0.0011 to 0.0021) | 0.55 |
| Reference model +ALP | 0.653 (0.579–0.727) | –0.001 | 0.97 | 0.0659 (–0.168 to 0.30) | 0.58 | 0.0016 (–0.0039 to 0.0071) | 0.56 |
| Reference model + γ-GTP | 0.652 (0.578–0.727) | –0.002 | 0.57 | –0.104 (–0.362 to 0.155) | 0.43 | 0.000272 (0.00245 to 0.00217) | 0.85 |
| Reference model +PIIINP (high/low) | 0.657 (0.583–0.731) | 0.003 | 0.76 | –0.063 (–0.336 to 0.209) | 0.65 | 0.0022 (–0.0035 to 0.008) | 0.45 |
| Reference model +PIIINP (continuous) | 0.663 (0.589–0.738) | 0.009 | 0.47 | 0.112 (–0.157 to 0.382) | 0.41 | 0.007 (–0.0012 to 0.0152) | 0.095 |
| Reference model +P4 NP 7S (high/low) | 0.675 (0.60–0.751) | 0.021 | 0.68 | 0.285 (0.016 to 0.555) | 0.038 | 0.019 (0.0052 to 0.033) | 0.007 |
| Reference model +P4 NP 7S (continuous) | 0.671 (0.599–0.743) | 0.017 | 0.33 | 0.382 (0.112 to 0.652) | 0.006 | 0.011 (0.00109 to 0.0209) | 0.041 |
The reference model included age, sex, EF<40%, eGFR, sodium <140 mmol/L, haemoglobin and BNP.
ALP, alkaline phosphatase; AST, aspartate aminotransferase; BNP, brain natriuretic peptide; EF, ejection fraction; eGFR, estimated glomerular filtration rate; γ-GTP, γ-glutamyltransferase; IDI, integrated discrimination improvement; NRI, net reclassification improvement; PIIINP, N-terminal propeptide of procollagen type III; P4NP 7S, 7S domain of the collagen type IV N-terminal propeptide; T-Bil, total bilirubin.