Table 3

Logistic regression analysis: associations between the clinical profiles and ‘rEF at second LVEF assessment’

	Univariable			Multivariable
	OR	95% CI	P value	OR	95% CI	P value
Age	0.988	0.978 to 0.999	0.028	0.974	0.953 to 0.995	0.016
Male gender	1.610	1.157 to 2.242	0.005	0.998	0.505 to 1.971	0.995
Body mass index	0.948	0.909 to 0.988	0.012	0.933	0.865 to 1.007	0.073
Systolic blood pressure	0.999	0.994 to 1.004	0.666
Heart rate	1.016	1.010 to 1.022	<0.001	1.012	0.996 to 1.029	0.138
NYHA class III or IV	1.212	0.521 to 2.819	0.655
Coronary artery disease	2.079	1.499 to 2.885	<0.001	2.112	1.047 to 4.259	0.037
Atrial fibrillation	1.317	0.958 to 1.809	0.090
Hypertension	1.391	0.968 to 1.997	0.074
Diabetes	1.609	1.168 to 2.217	0.004	1.517	0.789 to 2.915	0.211
Dyslipidaemia	1.048	0.739 to 1.489	0.795
Chronic kidney disease	1.514	1.099 to 2.084	0.011	0.694	0.342 to 1.409	0.312
Anaemia	1.700	1.225 to 2.360	0.001	1.378	0.699 to 2.719	0.355
Hyperuricaemia	2.432	1.717 to 3.443	<0.001	1.372	0.681 to 2.762	0.376
Sleep-disordered breathing	2.099	1.526 to 2.888	<0.001	1.212	1.007 to 1.472	0.042
COPD	1.265	0.885 to 1.810	0.197
Peripheral artery disease	1.606	0.993 to 2.596	0.093
Smoking	0.948	0.691 to 1.302	0.743
Alcohol	0.648	0.346 to 1.212	0.175
Log BNP	2.600	1.864 to 3.628	<0.001	1.543	0.845 to 2.817	0.158
Log troponin I	1.465	1.222 to 1.756	<0.001	1.574	1.055 to 2.349	0.026
LVDd	1.080	1.059 to 1.101	<0.001	1.069	1.030 to 1.109	<0.001
LVEF	0.908	0.888 to 0.927	<0.001	0.933	0.902 to 0.966	<0.001
CLBBB	2.791	0.809 to 9.634	0.104
QRS	1.008	1.001 to 1.015	0.026	0.997	0.983 to 1.011	0.662
QT	0.999	0.995 to 1.003	0.559
QTc	1.008	1.003 to 1.012	0.002	1.004	0.995 to 1.013	0.409
RAS inhibitors	0.725	0.547 to 0.936	0.037	0.931	0.472 to 1.388	0.281
Mineral receptor antagonist	0.926	0.562 to 1.324	0.463
Calcium channel blocker	0.893	0.647 to 1.234	0.494
Beta blocker	0.892	0.413 to 1.326	0.782
Diuretic	2.879	1.975 to 4.197	<0.001	2.272	0.970 to 5.320	0.414
Statin	1.297	0.943 to 1.783	0.110
Digitalis	1.501	0.915 to 2.462	0.108
ICD	1.180	0.744 to 1.871	0.482

BNP, B-type natriuretic peptide; CLBBB, complete left bundle branch block; COPD, chronic obstructive pulmonary disease; HFpEF, heart failure with preserved LVEF; ICD, implantable cardiac defibrillator; LVDd, left ventricular end diastolic dimension; LVEF, left ventricular ejection fraction; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; RAS, renin–angiotensin–aldosterone system; rEF, reduced LVEF at second assessment.