Table 2

HRs with 95% CIs for secondary endpoints

	N (NOAC/warfarin)	Apixaban 5/2.5 mg twice daily over warfarin	Dabigatran 150/110 mg twice daily over warfarin	Edoxaban 60/30 mg once daily over warfarin	Rivaroxaban 15/10 mg once daily over warfarin
	N (NOAC/warfarin)	22 752/19 059	8 003/19 059	12 592/19 059	17 481/19 059
Ischaemic stroke	HR	0.63	0.90	0.74	0.74
	95% CI	(0.524 to 0.759)	(0.716 to 1.140)	(0.586 to 0.925)	(0.607 to 0.909)
	P value	<0.0001	0.3906	0.0087	0.0039
Haemorrhagic stroke	HR	0.75	0.41	0.73	0.63
	95% CI	(0.545 to 1.029)	(0.244 to 0.703)	(0.479 to 1.102)	(0.432 to 0.922)
	P value	0.0743	0.0011	0.1332	0.0175
Systemic embolism	HR	0.48	0.97	0.46	0.50
	95% CI	(0.198 to 1.165)	(0.316 to 2.959)	(0.145 to 1.487)	(0.183 to 1.349)
	P value	0.1050	0.9519	0.1966	0.1701
Major GI bleeding	HR	0.76	0.92	0.83	0.92
	95% CI	(0.579 to 0.987)	(0.655 to 1.286)	(0.602 to 1.158)	(0.693 to 1.213)
	P value	0.0394	0.6175	0.2798	0.5425
Any GI bleeding	HR	0.87	1.04	0.99	0.87
	95% CI	(0.779 to 0.970)	(0.901 to 1.203)	(0.871 to 1.125)	(0.768 to 0.976)
	P value	0.0121	0.5870	0.8812	0.0186
Major intracranial haemorrhage	HR	0.58	0.42	0.60	0.52
	95% CI	(0.452 to 0.757)	(0.283 to 0.637)	(0.427 to 0.836)	(0.379 to 0.702)
	P value	<0.0001	<0.0001	0.0026	<0.0001
Any intracranial haemorrhage	HR	0.89	0.79	0.92	0.81
	95% CI	(0.781 to 1.010)	(0.658 to 0.946)	(0.789 to 1.076)	(0.701 to 0.936)
	P value	0.0715	0.0104	0.3014	0.0044