Table 5

Harrell’s C-statistics for evaluation of overall adequacy of risk prediction procedures

ProteinModel 3 vs model with add-on of each protein
GDF-150.693 vs 0.694
MMP-20.693 vs 0.698
UPAR0.693 vs 0.695
OPN0.693 vs 0.701
IGFBP-70.693 vs 0.696
PON30.693 vs 0.693
TNFR10.693 vs 0.693
NT-proBNP0.693 vs 0.750
CHI3L10.693 vs 0.693
FABP-40.693 vs 0.696
GAL-40.693 vs 0.694
Z-score0.693 vs 0.701
  • Model 3 is adjusted for age, sex, body mass index, systolic blood pressure, smoking status, prevalent diabetes mellitus, prevalent coronary events, prevalent heart failure and antihypertensive treatment.

  • CHI3L1, chitinase-3-like protein 1; FABP4, fatty-acid binding protein 4; GAL-4, galectin 4; GDF-15, growth differentiation factor 15; IGFBP-7, insulin-like growth factor-binding protein 7; MMP-2, matrix metalloproteinase-2; NT-proBNP, N-terminal pro-B-type natriuretic peptide; OPN, osteopontin; PON3, paraoxonase 3; TNFR1, tumour necrosis factor receptor 1; UPAR, urokinase receptor.