Table 3

Cox regression analysis in 140 patients with severe AS undergoing an uncomplicated TAVI

VariablesUnivariate*Bivariate models with adjusted postprocedural MD†Bivariate models with adjusted ∆MD
HR (95% CI)P valueHR (95% CI)P valueHR (95% CI)P value
CAD history1.51 (0.63 to 3.62)0.351.47 (0.61 to 3.52)0.381.55 (0.65 to 3.71)0.32
1.23 (1.01 to 1.50) *0.051.49 (1.19 to 1.88) †0.001
Gender1.80 (0.75 to 4.31)0.191.84 (0.77 to 4.42)0.171.65 (0.69 to 3.98)0.27
1.23 (1.01 to 1.49) *0.041.47 (1.17 to 1.84) †0.001
GLS per % increase1.03 (0.92 to 1.15)0.670.99 (0.88 to 1.11)0.880.99 (0.89 to 1.12)0.97
1.24 (1.00 to 1.55) *0.051.50 (1.18 to 1.91) †0.001
Logistic EuroSCORE1.01 (0.97 to 1.05)0.581.01 (0.97 to 1.05)0.691.01 (0.97 to 1.05)0.69
1.23 (0.99 to 1.53) *0.061.50 (1.19 to 1.89) †0.001
LVEF per % increase0.98 (0.94 to 1.03)0.410.99 (0.95 to 1.03)0.570.99 (0.95 to 1.03)0.53
1.23 (1.00 to 1.51) *0.051.49 (1.18 to 1.88) †0.001
MD per 10 ms increase1.23 (1.01 to 1.51)0.04
∆MD per 10 ms increase1.50 (1.18 to 1.89)0.001
New LBBB (yes/no)1.11 (0.41 to 3.01)0.840.94 (0.34 to 2.57)0.900.61 (0.21 to 1.73)0.35
1.24 (1.01 to 1.52) *0.041.56 (1.22 to 1.99) †<0.001
∆QRS duration, per 10 ms increase1.01 (0.99 to 1.03)0.201.10 (0.94 to 1.29)0.241.02 (0.86 to 1.22)0.80
1.28 (1.03 to 1.59) *0.031.58 (1.23 to 2.03) †<0.001
∆ZVA, per mm Hg m2/mL decrease1.04 (0.72 to 1.51)0.831.12 (0.76 to 1.64)0.581.24 (0.85 to 1.82)0.26
1.20 (0.94 to 1.53) *0.141.55 (1.17 to 2.05) †0.002
  • Rows marked with footnote symbols (*, †) contain bivariate HR values for postprocedural MD and MD, respectively.

  • AS, aortic stenosis; CAD, coronary artery disease; GLS, global longitudinal strain; LBBB, left bundle branch block; LVEF, left ventricular ejection fraction; MD, mechanical dispersion; TAVI, transcatheter aortic valve implantation; ZVA, valvulo-arterial impedance.