Partial correlations of resting heart rate with inflammatory/coagulation factors: the Multi-Ethnic Study of Atherosclerosis, 2000–2002*
| Marker | Whole cohort | Males | Females | |||
| N | r (p value) | N | r (p value) | N | r (p value) | |
| hs-CRP | 6714 | 0.15 (p<0.001) | 3173 | 0.18 (p<0.001) | 3541 | 0.12 (p<0.001) |
| Interleukin-6 | 6576 | 0.15 (p<0.001) | 3101 | 0.17 (p<0.001) | 3475 | 0.13 (p<0.001) |
| Fibrinogen | 6721 | 0.15 (p<0.001) | 3181 | 0.19 (p<0.001) | 3540 | 0.13 (p<0.001) |
| D-dimer | 6721 | 0.03 (p=0.005) | 3182 | 0.04 (p=0.02) | 3539 | 0.03 (p=0.12) |
| VWF | 992 | 0.10 (p=0.002) | 425 | 0.07 (p=0.14) | 567 | 0.12 (p=0.01) |
| Factor VIII | 6717 | 0.12 (p<0.001) | 3179 | 0.11 (p<0.001) | 3538 | 0.12 (p<0.001) |
| PAP | 6584 | 0.05 (p<0.001) | 3119 | 0.08 (p<0.001) | 3465 | 0.002 (p=0.91) |
| PAI-1 | 968 | 0.13 (p<0.001) | 418 | 0.16 (p=0.002) | 550 | 0.11 (p=0.01) |
| STM | 992 | 0.03 (p=0.39) | 426 | −0.01 (p=0.77) | 566 | 0.08 (p=0.07) |
| E-selectin | 994 | 0.16 (p<0.001) | 426 | 0.21 (p<0.001) | 568 | 0.11 (p=0.01) |
| ICAM-1 | 2610 | 0.07 (p<0.001) | 1146 | 0.07 (p=0.03) | 1464 | 0.07 (p=0.01) |
r, Spearman’s correlation.
*Adjusted for age, sex (except in sex stratified analysis), and race/ethnicity.
hsCRP, high sensitivity C reactive protein; ICAM-1, Intercellular adhesion molecule 1; PAI-1, plasminogen activator inhibitor-1; PAP, plasmin–antiplasmin; STM, soluble thrombomodulin; VWF, von Willebrand factor.