Lipoprotein subfractions by chemical analysis and NMR spectroscopy in US-White men in Allegheny County, USA, and Japanese men in Kusatsu, Japan, 2002–2006
| Lipids and lipoprotein profile | US-White men (n=270) | Japanese men (n=300) | P value | ||
| Mean | SD | Mean | SD | ||
| Standard lipids | |||||
| Total cholesterol, mmol/L | 5.6 | 1.0 | 5.6 | 0.9 | 0.554 |
| LDL-C, mmol/L | 3.6 | 0.9 | 3.4 | 0.9 | 0.070 |
| HDL-C, mmol/L | 1.2 | 0.3 | 1.4 | 0.4 | 0.011 |
| Triglycerides, mmol/L | 1.7 | 1.2 | 1.7 | 0.9 | 0.734 |
| NMR-measured lipoprotein particles | |||||
| LDL particles | |||||
| Total LDL-P, nmol/L | 1480.6 | 339.6 | 1469.4 | 400.9 | 0.721 |
| Small LDL-P, nmol/L | 686.6 | 358.9 | 663.1 | 358.0 | 0.432 |
| Large LDL-P, nmol/L | 661.1 | 314.1 | 654.0 | 254.2 | 0.774 |
| IDL-P, nmol/L | 132.9 | 100.1 | 152.3 | 112.0 | 0.031 |
| LDL particle size, nm | 20.9 | 0.7 | 20.9 | 0.7 | 0.192 |
| HDL particles | |||||
| Total HDL-P, μmol/L | 31.2 | 5.8 | 35 .6 | 6.8 | <0.001 |
| Small HDL-P, μmol/L | 20.5 | 4.4 | 17.2 | 5.6 | <0.001 |
| Medium HDL-P, μmol/L | 7.7 | 4.0 | 12.1 | 6.3 | <0.001 |
| Large HDL-P, μmol/L | 3.1 | 2.7 | 6.3 | 3.6 | <0.001 |
| HDL particle size, nm | 8.5 | 0.6 | 9.1 | 0.6 | <0.001 |
| VLDL particles | |||||
| Total VLDL-P, nmol/L | 83.5 | 43.2 | 87.5 | 47.5 | 0.285 |
| Small VLDL-P, nmol/L | 40.3 | 24.0 | 44.9 | 28.0 | 0.031 |
| Medium VLDL-P*, nmol/L | 32.0 | (14.0–53.0) | 32.0 | (15.0–53.0) | 0.813 |
| Large VLDL-P*, nmol/L | 3.0 | (1.0–7.0) | 1.0 | (0.0–4.0) | <0.001 |
| VLDL particle size, nm | 47.0 | 7.8 | 44.8 | 7.1 | <0.001 |
All continuous nearly normally distributed variables expressed in mean (SD) and compared using a two-sample t-test.
*Continuous variables with skewed distribution were expressed in median (IQR) and compared using the Mann-Whitney U test.
HDL, high-density lipoprotein; IDL, intermediate-density lipoprotein; LDL, low-density lipoprotein;NMR, nuclear magnetic resonance; VLDL, very low-density lipoprotein.