Multivariable-adjusted PR of race/ethnicity, % change in PR, IDI and NRI for CCS ≥10 when NMR-measured lipoproteins were added to referent model
| Robust Poisson regression models | PR (95% CI) | % change in PR compared with model II* | IDI (SE) | NRI (SE) |
| Model I | 2.03 (1.23 to 3.34) | – | – | – |
| Model II† | 2.10 (1.24 to 3.48) | – | – | – |
| Model II-A | 1.86 (1.07 to 3.26) | −11.43 | 0.000 (0.002) | 0.028 (0.025) |
| Model II-B | 2.08 (1.18 to 3.47) | −1.00 | 0.000 (0.000) | 0.006 (0.005) |
| Model II-C | 1.98 (1.18 to 3.31) | −5.71 | 0.003 (0.002) | −0.004 (0.025) |
| Model II-D | 2.01 (1.26 to 3.47) | −4.30 | 0.000 (0.000) | 0.006 (0.011) |
| Model III-A | 1.75 (1.05 to 3.08) | −16.67 | 0.003 (0.003) | −0.006 (0.031) |
| Model III-B | 1.80 (1.07 to 3.24) | −14.29 | 0.000 (0.002) | 0.026 (0.025) |
| Model IV-A | 1.73 (1.02 to 3.08) | −17.62 | 0.003 (0.003) | −0.021 (0.033) |
| Model IV-B | 1.79 (1.07 to 3.23) | −14.76 | 0.001 (0.002) | 0.028 (0.022) |
Model I: race, age, BMI, pack-year of smoking, hypertension, diabetes, triglyceride, LDL-C, HDL-C.
Model II-A: model II+large HDL-P.
Model II-B: model II+HDL particle size.
Model II-C: model II+VLDL particle size.
Model II-D: model II+large VLDL-P.
Model III-A: model II+large HDL-P+VLDL particle size.
Model III-B: model II+large HDL-P+large VLDL-P.
Model IV-A: model II+total LDL-P+large HDL-P+VLDL particle size.
Model IV-B: model II+total LDL-P+large HDL-P+large VLDL-P.
Reclassification categories for NRI: <5.0%, 5.0%–9.9%, 10.0%–19.9% and high ≥20%.
CRP, triglycerides, ethanol intake, large VLDL-P and medium VLDL-P were log transformed after addition of one unit. All other continuous variables were standardised.
*Per cent change in PR for race compared with model II was calculated as: ((PR for race/ethnicity in model II)–(PR for race/ethnicity in each model (model II-A to IV-B)))×100/(PR for race/ethnicity in model II).
†Model II (referent model): model I+alcohol intake+CRP+fibrinogen.
CRP, C reactive protein; HDL-C, high-density lipoprotein cholesterol; HDL-P, high-density lipoprotein particles; IDI, Integrated Discrimination Improvement;LDL-C, low-density lipoprotein cholesterol; LDL-P, low-density lipoprotein particles; NRI, Net Reclassification Improvement; PR, prevalence ratio; VLDL-P, very low-density lipoprotein particles.