Table 4

Adjusted HRs for AMI or CHD death and 95% CIs for time-updated mean HbA1c categories together with albuminuria and eGFR versus the reference group examined by Cox regression

AMI or CHD deathHR (95% CI) P value
Model 3
All patients and controls
Model 3a
Male patients and controls
Model 3b
Female patients and controls
Time-updated mean HbA1c categories albuminuria and eGFREvents (n)=136 231
Subjects (n)=2 445 866
Events (n)=84 382
Subjects (n)=1 323 072
Events (n)=51 849
Subjects (n)=1 122 794
Controls (reference)1.001.001.00
 ≤6.9% (≤52 mmol/mol):normoalbuminuria and eGFR ≥600.95 (0.92 to 0.98)
0.0009
0.94 (0.90 to 0.98)
0.0014
0.98 (0.93 to 1.04)
0.56
 7.0%–7.8% (53–62 mmol/mol):normoalbuminuria and eGFR ≥601.21 (1.16 to 1.25)
<0.0001
1.16 (1.11 to 1.22)
<0.0001
1.31 (1.23 to 1.40)
<0.0001
 7.9%–8.7% (63–72 mmol/mol):normoalbuminuria and eGFR ≥601.63 (1.54 to 1.72)
<0.0001
1.51 (1.41 to 1.62)
<0.0001
1.87 (1.71 to 2.04)
<0.0001
 8.8%–9.6% (73–82 mmol/mol): normoalbuminuria and eGFR ≥601.92 (1.75 to 2.10)
<0.0001
1.75 (1.56 to 1.96)
<0.0001
2.25 (1.94 to 2.60)
<0.0001
 ≥9.7% (≥83 mmol/mol):normoalbuminuria and eGFR ≥602.73 (2.42 to 3.09)
<0.0001
2.51 (2.16 to 2.93)
<0.0001
3.09 (2.53 to 3.78)
<0.0001
 ≤6.9% (≤52 mmol/mol):not normoalbuminuria or eGFR <601.40 (1.37 to 1.44)
<0.0001
1.39 (1.34 to 1.43)
<0.0001
1.42 (1.36 to 1.47)
<0.0001
 7.0%–7.8% (53–62 mmol/mol):not normoalbuminuria or eGFR <601.70 (1.65 to 1.75)
<0.0001
1.65 (1.58 to 1.71)
<0.0001
1.78 (1.69 to 1.86)
<0.0001
 7.9%–8.7% (63–72 mmol/mol):not normoalbuminuria or eGFR <602.11 (2.03 to 2.20)
<0.0001
2.04 (1.94 to 2.15)
<0.0001
2.21 (2.07 to 2.35)
<0.0001
 8.8%–9.6% (73–82 mmol/mol):not normoalbuminuria or eGFR <602.48 (2.33 to 2.63)
<0.0001
2.41 (2.23 to 2.60)
<0.0001
2.56 (2.33 to 2.81)
<0.0001
 ≥9.7% (≥83 mmol/mol): not normoalbuminuria or eGFR <602.94 (2.71 to 3.19)
<0.0001
2.77 (2.49 to 3.09)
<0.0001
3.14 (2.77 to 3.56)
<0.0001
  • Adjusted for time-updated age and sex (for all patient models), time-updated diabetes duration (centred at median 8 years), born in Sweden, maximum education level and baseline comorbidities (AF, CHD, HF, VD, stroke, cancer).

  • AF, atrial fibrillation; AMI, acute myocardial infarction; CHD, coronary heart disease; HF, heart failure; VD, valve disease; eGFR, estimated glomerular filtration rate.