Baseline characteristics between eras in patients undergoing intervention for severe AS
| All intervention (N=705) | Intervention pre-TAVR era (n=191) | Intervention post-TAVR era (n=514) | P value | |
| Demography | ||||
| Age, median (IQR) | 76.4 (67.6–82.2) | 74 (65.8–79.6) | 77 (68.8–83.4) | <0.001 |
| Gender, n (%) | 289 (41.0) | 77 (40.3) | 212 (41.2) | 0.82 |
| BMI, median (IQR) | 28 (24.4–34.6) | 27 (24.4–33.2) | 28 (24.5–34.7) | 0.45 |
| eGFR (MDRD), median (IQR) | 72 (53.8–86.2) | 75.2 (54–85.8) | 69.4 (53.6–86.6) | 0.17 |
| Echocardiographic parameters | ||||
| AV mean gradient (mm Hg), median (IQR) | 40 (30–48.2) | 38.4 (28.9–47.9) | 40 (31–48.2) | 0.19 |
| AV area (cm2), median (IQR) | 0.8 (0.6–1) | 0.8 (0.6–1) | 0.8 (0.6–1) | 0.13 |
| AV peak velocity (m/s), median (IQR) | 4 (3.6–4.4) | 4 (3.6–4.5) | 4 (3.6–4.4) | 0.19 |
| DPI, median (IQR) | 0.2 (0.2–0.2) | 0.2 (0.2–0.2) | 0.2 (0.2–0.2) | 0.096 |
| Severe AV mean gradient, n (%) | 358 (50.8) | 92 (48.2) | 266 (51.8) | 0.40 |
| Severe AV peak velocity, n (%) | 425 (60.3) | 100 (52.4) | 325 (63.2) | 0.009 |
| Severe AV area, n (%) | 521 (73.9) | 117 (61.3) | 404 (78.6) | <0.001 |
| Severe DPI, n (%) | 448 (63.5) | 113 (59.2) | 335 (65.2) | 0.14 |
| 1 Severe AS factor, n (%) | 177 (25.1) | 63 (33.0) | 114 (22.2) | 0.003 |
| 2 Severe AS factors, n (%) | 196 (27.8) | 57 (29.8) | 139 (27.0) | 0.46 |
| 3 Severe AS factors, n (%) | 141 (20.0) | 39 (20.4) | 102 (19.8) | 0.87 |
| 4 Severe AS factors, n (%) | 190 (27.0) | 32 (16.8) | 158 (30.7) | <0.001 |
| Ejection fraction (%), median (IQR) | 64.4 (51.8–75.6) | 73.4 (58.4–80) | 62 (49.8–71.4) | <0.001 |
| Normal LV, n (%) | 504 (71.5) | 151 (79.1) | 353 (68.7) | 0.007 |
| Mild LV dysfunction, n (%) | 76 (10.8) | 21 (11.0) | 55 (10.7) | 0.91 |
| Moderate LV dysfunction, n (%) | 64 (9.1) | 10 (5.2) | 54 (10.5) | 0.030 |
| Severe LV dysfunction, n (%) | 38 (5.4) | 8 (4.2) | 30 (5.8) | 0.39 |
| Comorbidities | ||||
| Prior HF, n (%) | 101 (14.3) | 26 (13.6) | 75 (14.6) | 0.74 |
| Prior HTN, n (%) | 251 (35.6) | 62 (32.5) | 189 (36.8) | 0.29 |
| Prior ACS, n (%) | 183 (26.0) | 51 (26.7) | 132 (25.7) | 0.78 |
| Prior CVA, n (%) | 20 (2.8) | 5 (2.6) | 15 (2.9) | 0.83 |
| Prior COPD, n (%) | 45 (6.4) | 16 (8.4) | 29 (5.6) | 0.19 |
| Prior liver disease, n (%) | 13 (1.8) | 2 (1.0) | 11 (2.1) | 0.34 |
| Prior dementia, n (%) | 3 (0.4) | 1 (0.5) | 2 (0.4) | 0.81 |
| Prior diabetes, n (%) | 149 (21.1) | 42 (22.0) | 107 (20.8) | 0.73 |
| Prior cancer, n (%) | 116 (16.5) | 26 (13.6) | 90 (17.5) | 0.21 |
| Prior CABG, n (%) | 31 (4.4) | 5 (2.6) | 26 (5.1) | 0.16 |
ACS, acute coronary syndrome; AS, aortic stenosis; AV, aortic valve; BMI, body mass index; CABG, coronary artery bypass grafting; COPD, chronic obstructive pulmonary disease; CVA, cerebrovascular accident; DPI, Dimensionless Performance Index;eGFR, estimated glomerular filtration rate; HF, heart failure; HTN, hypertension; LV, left ventricular;MDHT, multidisciplinary heart team; MDRD, Modification of Diet for Renal Disease;TAVR, transcatheter aortic valve replacement.