Table 1

Baseline characteristics of patients with severe AS, with comparisons of characteristics prior and subsequent to the era defined by the MDHT

Overall (N=3399)Pre-TAVR era (n=999)Post-TAVR era (n=2400)P value
Demography
 Age, median (IQR)81.6 (73.4–87.2)81 (73.2–86.6)81.8 (73.4–87.6)0.019
 Female gender, n (%)1683 (49.5)525 (52.6)1158 (48.2)0.022
 BMI, median (IQR)27 (23.8–31.2)26.8 (24.2–29.4)27 (23.8–31.4)0.70
 eGFR (mL/min/1.73 m2), median (IQR)63.2 (45.6–80.6)61.2 (43.8–80.4)64 (46.6–80.6)0.006
Echocardiographic parameters
 AV mean gradient (mm Hg), median (IQR)30.2 (19.6–41.8)28.8 (17.4–41)30.8 (20.2–42)<0.001
 AV Area (cm2), median (IQR)0.8 (0.6–1)0.8 (0.6–1)0.8 (0.8–1)<0.001
 AV peak velocity (m/s), median (IQR)3.6 (3–4.2)3.6 (2.8–4.2)3.6 (3–4.2)0.006
 DPI, median (IQR)0.2 (0.2–0.2)0.2 (0.2–0.4)0.2 (0.2–0.2)<0.001
 Severe AV mean gradient, n (%)1093 (32.2)319 (31.9)774 (32.2)0.86
 Severe AV peak velocity, n (%)1360 (40.0)351 (35.1)1009 (42.0)<0.001
 Severe AV area, n (%)2525 (74.3)686 (68.7)1839 (76.6)<0.001
 Severe DPI, n (%)1753 (51.6)494 (49.4)1259 (52.5)0.11
 1 Severe AS factor, n (%)1465 (43.1)487 (48.7)978 (40.8)<0.001
 2 Severe AS factors, n (%)1024 (30.1)277 (27.7)747 (31.1)0.049
 3 Severe AS factors, n (%)418 (12.3)131 (13.1)287 (12.0)0.35
 4 Severe AS factors, n (%)491 (14.4)104 (10.4)387 (16.1)<0.001
 Ejection fraction (%), median (IQR)61.2 (46.8–73)65.4 (49.4–77.6)60 (45.6–70.4)<0.001
 Normal LV, n (%)2311 (68.0)688 (68.9)1623 (67.6)0.48
 Mild LV dysfunction, n (%)425 (12.5)134 (13.4)291 (12.1)0.30
 Moderate LV dysfunction, n (%)334 (9.8)78 (7.8)256 (10.7)0.011
 Severe LV dysfunction, n (%)279 (8.2)98 (9.8)181 (7.5)0.028
Comorbidities
 Prior HF, n (%)715 (21.0)239 (23.9)476 (19.8)0.008
 Prior HTN, n (%)1292 (38.0)370 (37.0)922 (38.4)0.45
 Prior ACS, n (%)895 (26.3)294 (29.4)601 (25.0)0.008
 Prior CVA, n (%)122 (3.6)27 (2.7)95 (4.0)0.073
 Prior COPD, n (%)347 (10.2)120 (12.0)227 (9.5)0.025
 Prior liver disease, n (%)89 (2.6)27 (2.7)62 (2.6)0.84
 Prior dementia, n (%)75 (2.2)29 (2.9)46 (1.9)0.075
 Prior diabetes, n (%)662 (19.5)189 (18.9)473 (19.7)0.60
 Prior cancer, n (%)628 (18.5)180 (18.0)448 (18.7)0.66
 Prior CABG, n (%)128 (3.8)31 (3.1)97 (4.0)0.19
  • ACS, acute coronary syndrome; AS, aortic stenosis; AV, aortic valve; BMI, body mass index; CABG, coronary artery bypass grafting; COPD, chronic obstructive pulmonary disease; CVA, cerebrovascular accident; DPI, Dimensionless Performance Index;HF, heart failure; HTN, hypertension; LV, left ventricular;MDHT, multidisciplinary heart team; MDRD, Modification of Diet for Renal Disease;TAVR, transcatheter aortic valve replacement; eGFR, estimated glomerular filtration rate.