Univariable | Multivariable | |||
Slope with 95% CI | P value | Slope with 95% CI | P value | |
Age | −0.3% (−0.6% to 0.0%) | 0.045 | −0.2% (−0.6% to 0.1%) | 0.185 |
Female | −0.8% (−7.9% to 6.2%) | 0.819 | −3.1% (−10.4% to 4.2%) | 0.399 |
Total scar (per 1% increase) | −0.4% (−0.6% to −0.2%) | <0.001 | −0.6% (−0.9% to −0.3%) | <0.001 |
LBBB | 7.4% (0.9% to 14.0%) | 0.028 | 8.9% (0.4% to 17.4%) | 0.040 |
QRS width | 0.1% (−0.1% to 0.2%) | 0.409 | −0.1% (−0.3% to 0.1%) | 0.390 |
Diabetes | −1.6% (−10.0% to 6.8%) | 0.706 | 0.2% (−8.5% to 8.9%) | 0.964 |
Hypertension | −0.7% (−7.7% to 6.3%) | 0.851 | −2.4% (−9.6% to 4.8%) | 0.501 |
LV lead tip in scar | −4.7% (−12.5% to 3.1%) | 0.229 | 6.1% (−2.6% to 14.8%) | 0.165 |
Unipolar lead | −7.5% (−15.5% to 0.4%) | 0.064 | 3.3% (−5.7% to 12.3%) | 0.460 |
Slope is the mean change in ejection fraction difference. On multivariable analysis, only increase in scar burden and absence of LBBB were associated with lack of echocardiographic response to CRT.
LBBB, left bundle branch block; LV, left ventricle; QRS, QRS complex duration in ms.