Table 4

Univariable and multivariable associations for the echocardiographic endpoint

UnivariableMultivariable
Slope with 95% CIP valueSlope with 95% CIP value
Age−0.3% (−0.6% to 0.0%)0.045−0.2% (−0.6% to 0.1%)0.185
Female−0.8% (−7.9% to 6.2%)0.819−3.1% (−10.4% to 4.2%)0.399
Total scar (per 1% increase)−0.4% (−0.6% to −0.2%)<0.001−0.6% (−0.9% to −0.3%)<0.001
LBBB7.4% (0.9% to 14.0%)0.0288.9% (0.4% to 17.4%)0.040
QRS width0.1% (−0.1% to 0.2%)0.409−0.1% (−0.3% to 0.1%)0.390
Diabetes−1.6% (−10.0% to 6.8%)0.7060.2% (−8.5% to 8.9%)0.964
Hypertension−0.7% (−7.7% to 6.3%)0.851−2.4% (−9.6% to 4.8%)0.501
LV lead tip in scar−4.7% (−12.5% to 3.1%)0.2296.1% (−2.6% to 14.8%)0.165
Unipolar lead−7.5% (−15.5% to 0.4%)0.0643.3% (−5.7% to 12.3%)0.460
  • Slope is the mean change in ejection fraction difference. On multivariable analysis, only increase in scar burden and absence of LBBB were associated with lack of echocardiographic response to CRT.

  • LBBB, left bundle branch block; LV, left ventricle; QRS, QRS complex duration in ms.