Table 2

Univariable and multivariable associations with the post cardiac resynchronisation therapy (CRT) clinical endpoints (heart failure admission or death)

	Univariable		Multivariable
	HR with 95% CI	P value	HR with 95% CI	P value
Age	1.04 (1.00 to 1.08)	0.035	1.07 (1.01 to 1.13)	0.017
Female	0.76 (0.36 to 1.61)	0.469	0.97 (0.43 to 2.22)	0.945
Total scar (per 1% increase)	1.05 (1.03 to 1.07)	<0.001	1.06 (1.02 to 1.10)	0.003
LBBB	0.55 (0.26 to 1.17)	0.119	0.29 (0.09 to 0.94)	0.039
QRS width	0.99 (0.98 to 1.01)	0.427	1.01 (0.98 to 1.04)	0.600
Diabetes	0.88 (0.37 to 2.09)	0.770	0.63 (0.23 to 1.73)	0.367
Hypertension	0.79 (0.36 to 1.74)	0.561	1.32 (0.53 to 3.32)	0.549
LV lead tip in scar	2.26 (0.84 to 6.08)	0.106	0.62 (0.16 to 2.37)	0.486
Unipolar lead	2.76 (1.24 to 6.14)	0.013	1.06 (0.34 to 3.28)	0.918

On multivariable analysis, only increasing age, increasing scar burden and absence of LBBB were associated with lack of clinical response to CRT (heart failure admission or death).
LBBB, left bundle branch block; LV, left ventricle; QRS, QRS complex duration in ms.