Adjusted* estimate of HR | ||||||||

Septal scar† | Anterior scar‡ | Lateral scar§ | Inferior scar¶ | |||||

A: clinical endpoint | Estimate | P value | Estimate | P value | Estimate | P value | Estimate | P value |

Time between CRT and death or heart failure admission | 1.03 | 0.002 | 1.03 | <0.001 | 1.03 | 0.005 | 1.02 | 0.017 |

Adjusted* estimate of slope | ||||||||

Septal scar† | Anterior scar‡ | Lateral scar§ | Inferior scar¶ | |||||

B: echocardiographic endpoint | Estimate | P value | Estimate | P value | Estimate | P value | Estimate | P value |

Change in EF after CRT | −0.26 | 0.002 | −0.24 | <0.001 | −0.20 | 0.044 | −0.31 | 0.008 |

*Adjusted estimates are from a model where the following covariates were included as predictors (in addition to total scar %): age, gender, presence of left bundle branch block, QRS duration, diabetes mellitus and hypertension.

†Septal scar was calculated as the average of the scar per cent in AHA segments 2, 3, 8, 9 and 14.

‡Anterior scar was calculated as the average of the scar per cent in AHA segments 1, 7 and 13.

§Lateral scar was calculated as the average of the scar per cent in AHA segments 5, 6, 11, 12 and 16.

¶Inferior scar was calculated as the average of the scar per cent in AHA segments 4, 10 and 15.

AHA, American Heart Association; CRT, cardiac resynchronisation therapy; EF, ejection fraction.