Table 3

Heritability estimates as estimated using structural equations modeling (SEM)

Monozygotic twin pairsControl pairsSEM (ACE model)
NNh2 (95% CI)C (95% CI)Best modelCE worse
(p value)
AE worse
(p value)
DCMLVEF8114.9% (0.0% to 84.5%)66.9% (0.0% to 86.6%)CE0.09
LVEDD71552.8% (0.0% to 91.2%)24.6% (0.0% to 76.6%)AE0.23
HCMIVSd11140.0% (0.0% to 43.6%)65.6% (20.1% to 83.4%)*CE0.02*
LQTSQTc253057.5% (5.5% to 87.5%)*23.7% (0.0% to 64.9%)AE0.03*
  • *Significant at the p<0.05 level or within the 95% CI.

  • ACE, additive genetic effects, common and unique environmental effects; AE, additive genetic effects and unique environmental effects; CE, common and unique environmental effects; DCM, dilated cardiomyopathy; HCM, hypertrophic cardiomyopathy; IVSd, diastolic interventricular septum thickness; LQTS, long QT syndrome; LVEDD, left ventricular end-diastolic dimension; LVEF, left ventricular ejection fraction; QTc, corrected QT interval.