Table 1

Analytical variation, biological variation, indexes of individuality and reference change values in stable aortic valve stenosis

Mean concentrationVariance componentsRCV†II
CVGCVICVA*NormalLog-normal
BNP5.7 pmol/L48.4
(28.6 to 91.7)
62.0
(52.5 to 75.4)
19.7
(17.1 to 23.4)
52.6; −34.51.3
NT-proBNP9.3 pmol/L43.0
(27.7 to 88.8)
22.0
(18.3 to 27.5)
1.9
(1.6 to 2.3)
44.6; −30.90.5
hs-TnT9.2 ng/L57.2
(40.4 to 97.3)
11.2
(9.6 to 13.5)
3.7
(3.2 to 4.3)
43.1; −30.10.2
hs-TnI3.6 ng/L35.0
(23.3 to 67.6)
9.2
(2.8 to 13.8)
14.9
(12.7 to 18.0)
73.1; −42.20.5
ST228.4 ng/mL19.8
(13.8 to 33.4)
13.1
(11.3 to 15.6)
2.0
(1.7 to 2.4)
36.83§0.7
  • Values are % (95% CI).

  • *On the basis of duplicate measurements.

  • †On the basis of a Z-score of 1.96.

  • ‡Non-normal distribution.

  • §Normal distribution.

  • BNP, brain natriuretic peptide;CVA, analytical coefficient of variation; CVG, between-person coefficient of variation; CVI, within-person biological coefficient of variation; II, index of individuality; NT-proBNP, N-terminus pro-brain natriuretic peptide;RCV, reference change value; hs-TnI, high-sensitivity troponin-I; hs-TnT, high-sensitivity troponin-T.