Table 3

Clinical outcomes at 3 years in the ACEI and ARB group in prespecified subgroups*

ACEI rate % (95% CI)ARB rate % (95% CI)HR (95% CI)†Interaction p value
Age (years)
 <7510.3 (9.8 to 10.7)10.1 (9.4 to 10.8)1.02 (0.93 to 1.12)0.155
 ≥7520.4 (19.9 to 20.9)18.8 (18.0 to 19.6)1.10 (1.04 to 1.17)
Sex
 Female18.0 (17.4 to 18.6)15.6 (14.7 to 16.5)1.17 (1.10 to 1.26)<0.001
 Male14.6 (14.1 to 15.0)14.7 (14.0 to 15.4)1.00 (0.93 to 1.06)
Prior diabetes
 Yes18.9 (18.4 to 19.5)18.1 (17.2 to 19.0)1.05 (0.99 to 1.12)0.576
 No13.5 (13.0 to 14.0)12.6 (11.9 to 13.3)1.08 (1.01 to 1.17)
Prior heart failure
 Yes28.7 (27.8 to 29.6)26.4 (25.1 to 27.8)1.12 (1.04 to 1.20)0.209
 No11.7 (11.4 to 12.1)11.2 (10.7 to 11.8)1.05 (0.98 to 1.12)
  • *Primary outcome defined as cardiovascular death, rehospitalisation for myocardial infarction and unstable angina.

  • †ARB inhibitor was the reference group.

  • ACEI, ACE inhibitor; ARB, angiotensin receptor blocker.