Crude | Adjusted | |||
MRI outcomes 2 days post-STEMI | β/OR (95% CI) | P value | β/OR (95% CI) | P value |
Infarct size (%LV mass) | −0.08 (−0.19 to 0.03) | 0.140 | −0.06 (−0.16 to 0.05) | 0.282 |
LVEF% | 0.10 (−0.01 to 0.21) | 0.086 | 0.05 (−0.05 to 0.16) | 0.327 |
LVESVi at 2 days, mL/m2 | −0.22 (−0.33 to −0.12) | <0.0001 | −0.17 (−0.27 to −0.07) | 0.002 |
LVEDVi at 2 days, mL/m2 | −0.30 (−0.40 to −0.19) | <0.0001 | −0.26 (−0.36 to −0.20) | <0.0001 |
Microvascular obstruction present | 0.64 (0.39 to 1.05) | 0.079 | 0.60 (0.35 to 1.02) | 0.060 |
Microvascular obstruction extent (%LV mass) | −0.12 (−0.22 to −0.01) | 0.039 | −0.10 (−0.21 to −0.01) | 0.077 |
Myocardial haemorrhage present | 0.50 (0.27 to 0.95) | 0.033 | 0.52 (0.26 to 1.03) | 0.060 |
T1 remote zone (ms) | 0.17 (0.06 to 0.29) | 0.003 | 0.18 (0.06 to 0.30) | 0.004 |
T1 infarct zone (ms) | 0.12 (0.00 to 0.24) | 0.042 | 0.11 (−0.01 to 0.23) | 0.063 |
T1 core zone (ms) | 0.04 (−0.12 to 0.20) | 0.615 | 0.07 (−0.09 to 0.23) | 0.398 |
T2 remote zone (ms) | 0.10 (−0.01 to 0.20) | 0.088 | 0.10 (−0.02 to 0.21) | 0.089 |
T2 infarct zone (ms) | −0.05 (−0.16 to 0.06) | 0.356 | −0.06 (−0.18 to 0.06) | 0.319 |
T2 core zone (ms) | −0.09 (−0.23 to 0.05) | 0.204 | −0.10 (−0.26 to 0.05) | 0.176 |
MRI outcomes 6 months post-STEMI | ||||
Myocardial salvage index (%LV mass) | 0.08 (−0.03 to 0.20) | 0.151 | 0.08 (−0.04 to 0.20) | 0.206 |
Infarct size (%LV mass) | −0.10 (−0.22 to 0.01) | 0.077 | −0.07 (−0.18 to 0.04) | 0.207 |
LVEF% | 0.13 (0.02 to 0.25) | 0.025 | 0.11 (0.00 to 0.23) | 0.060 |
LVESVi at 6 months, mL/m2 | −0.21 (−0.32 to −0.10) | <0.0001 | −0.19 (−0.31 to −0.08) | 0.001 |
LVEDVi at 6 months, mL/m2 | −0.27 (−0.38 to −0.16) | <0.0001 | −0.26 (−0.37 to −0.15) | <0.0001 |
Change in LVEDVi>20% | 0.92 (0.32 to 2.62) | 0.872 | −0.08 (−0.19 to 0.04) | 0.206 |
Persistent myocardial haemorrhage present | 0.48 (0.21 to 1.08) | 0.075 | 0.47 (0.20 to 1.13) | 0.092 |
T2 remote zone (ms) | 0.06 (−0.06 to 0.17) | 0.328 | 0.08 (−0.04 to 0.20) | 0.193 |
T2 infarct zone (ms) | 0.04 (−0.08 to 0.15) | 0.512 | 0.04 (−0.08 to 0.16) | 0.558 |
T2 core zone (ms) | −0.18 (−0.46 to 0.10) | 0.194 | 0.01 (−0.40 to 0.42) | 0.946 |
Angiography outcomes | ||||
TIMI frame count post-PCI | −0.15 (−0.26 to −0.04) | 0.007 | −0.17 (−0.28 to −0.05) | 0.004 |
TIMI myocardial perfusion grade post-PCI ≤1 | 0.51 (0.28 to 0.93) | 0.029 | 0.52 (0.28 to 0.97) | 0.040 |
Invasive coronary physiology outcomes | ||||
IMR >40(U) | 0.92 (0.51 to 1.64) | 0.771 | 0.90 (0.49 to 1.66) | 0.744 |
IMR(U) | −0.07 (−0.18 to 0.05) | 0.247 | −0.09 (−0.20 to 0.03) | 0.161 |
CFR≤2 | 0.94 (0.47 to 1.89) | 0.871 | 1.11 (0.54 to 2.30) | 0.777 |
CFR | −0.03 (−0.14 to 0.09) | 0.667 | −0.00 (−0.13 to 0.12) | 0.951 |
ECG outcomes | ||||
Incomplete ST-segment resolution | 0.89 (0.44 to 1.80) | 0.743 | 1.17 (0.55 to 2.46) | 0.687 |
MRI outcomes at 6 months were adjusted for prescription of beta-blocker on discharge, eGFR, reperfusion strategy (thrombolysis vs no thrombolysis), culprit artery territory (LAD/left main vs circumflex vs right coronary artery), age and ischaemic time. All other outcomes were adjusted for eGFR, reperfusion strategy (thrombolysis vs no thrombolysis), culprit artery territory (LAD/left main vs circumflex vs right coronary artery), age and ischaemic time.
CFR, coronary flow reserve; eGFR, estimated glomerular filtration rate; IMR, Index of microcirculatory resistance; LV, left ventricular; LVEDVi, LV end-diastolic volume index; LVEF, left ventricular ejection fraction; LVESVi, LV end-systolic volume index; PCI, percutaneous coronary intervention; STEMI, ST-segment elevation myocardial infarction; TIMI, Thrombolysis in Myocardial Infarction.