Table 4

Multivariable logistic regression of in-hospital mortality

Predictor	AVE			MVE
Predictor	OR	95% CI	P value	OR	95% CI	P value
ESRD	3.6	0.95 to 13	0.060	2.2	0.81 to 5.9	0.12
Female sex	1.2	0.65 to 2.2	0.55	2.2	1.3 to 3.6	0.002
Age*	1.04	1.01 to 1.06	0.003	1.04	1.02 to 1.07	<0.001
Diabetes†	0.91	0.44 to 1.9	0.81	0.74	0.38 to 1.5	0.38
IDU	1.2	0.25 to 5.4	0.84	1.3	0.33 to 5.0	0.72
Healthcare-associated	1.2	0.54 to 2.6	0.66	1.4	0.69 to 2.6	0.38
Pathogen
Alpha-haemolytic streptococci	(ref)			(ref)
Staphylococcus aureus	0.67	0.37 to 1.6	0.47	3.2	1.5 to 6.6	0.002
Enterococci	1.1	0.44 to 2.8	0.84	3.5	1.3 to 9.7	0.015
Other	0.86	0.36 to 2.0	0.73	1.6	0.64 to 3.8	0.33
Surgery for IE	0.16	0.061 to 0.40	<0.001	0.75	0.39 to 1.4	0.38
Brain emboli	3.4	1.6 to 7.2	0.001	2.3	1.3 to 4.0	0.004
Heart failure‡	4.8	2.7 to 8.8	<0.001	1.9	1.2 to 3.2	0.012
Vegetation§	1.2	0.47 to 3.2	0.69	0.75	0.32 to 1.7	0.50
Perivalvular involvement¶	2.9	0.93 to 9.0	0.067	0.74	0.22 to 2.5	0.63

*Increasing age per 1 year increment.
†Includes diabetes mellitus types 1 and 2.
‡Before or during treatment of IE.
§Any size visualised.
¶This includes any periannular spread beyond the confinements of the valve.
AVE, aortic valve infective endocarditis; ESRD, end-stage renal disease;IDU, injection drug use; IE, infective endocarditis; MVE, mitral valve infective endocarditis.