Multivariate Cox regression analyses for AVR in the total population and for the development of spontaneous or revealed symptoms on serial testing in patients who were asymptomatic on the baseline study
| Total study population (n=306) AVR | Asymptomatic on ETT (n=219) Revealed symptoms | |||
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Rapid early rise in heart rate | 2.15 (1.44 to 3.22) | <0.001 | 2.14 (1.07 to 4.27) | 0.03 |
| Age, year | 1.02 (1.00 to 1.03) | 0.025 | 1.05 (1.02 to 1.08) | <0.001 |
| Male sex | 1.82 (1.22 to 2.73) | 0.004 | 1.16 (0.66 to 2.01) | 0.611 |
| Hypertension | 0.83 (0.56 to 1.24) | 0.368 | 0.94 (0.47 to 1.91) | 0.871 |
| Doppler stroke volume, mL | 1.00 (0.99 to 1.01) | 0.354 | 1.00 (0.99 to 1.02) | 0.570 |
| Mean pressure gradient, mm Hg | 1.05 (1.03 to 1.06) | <0.001 | 1.02 (0.99 to 1.02) | 0.063 |
| Abnormal blood pressure response | 1.24 (0.86 to 1.80) | 0.253 | 1.87 (0.93 to 3.79) | 0.081 |
| Coronary artery disease | 0.99 (0.68 to 1.47) | 0.993 | 0.88 (0.42 to 1.84) | 0.940 |
AVR, aortic valve replacement; ETT, excercise treadmill test.