Table 1

Baseline clinical and echocardiographic characteristics of the study population according to the severity of AS

Total (n=306)Moderate AS (n=204)Severe AS (n=102)P value
Demographic and clinical data
 Age, years65±1264±1269±11<0.01
 Male, female %67, 3370, 3061, 390.134
 Obesity80 (26%)55 (27%)25 (25%)0.944
 Smokers147 (48%)96 (47%)51 (50%)0.586
 Coronary artery disease152 (50%)118 (58%)36 (35%)0.001
 Diabetes mellitus43 (14%)31 (15%)12 (12%)0.409
 Previous stroke or transient ischaemic attack37 (12%)28 (14%)9 (9%)0.233
 Atrial fibrillation43 (14%)21 (10%)22 (21%)0.056
 Hypercholesterolaemia202 (66%)144 (71%)58 (57%)0.029
 Clinic systolic BP, mm Hg142±19140±18145±210.052
 Clinic diastolic BP, mm Hg82±1381±1286±110.001
 Hypertension223 (73%)146 (72%)77 (75%)0.565
 Antihypertensive treatment199 (65%)133 (65%)66 (65%)0.992
  Beta blockers101 (33%)65 (32%)36 (35%)0.805
  Diuretics92 (30%)63 (31%)29 (28%)0.581
  Calcium blockers80 (26%)49 (24%)31 (29%)0.618
  ACE inhibitors60 (20%)49 (24%)11 (11%)0.036
  ARB inhibitors37 (12%)27 (13%)10 (10%)0.447
  Alpha blockers25 (8%)19 (9%)6 (6%)0.368
Echocardiographic data
 LV end-diastolic diameter, cm4.6±0.74.6±0.64.5±0.70.301
 Interventricular septal thickness, cm1.29±0.261.27±0.251.35±0.28<0.018
 Posterior wall thickness, cm1.12±0.221.10±0.201.15±0.26<0.036
 LV mass index, g/m2.7 52±1750±1655±200.098
 LV hypertrophy165 (54%)106 (52%)60 (59%)0.357
 LV ejection fraction %60±760±760±60.821
 Peak aortic jet velocity, m/s3.7±0.63.4±0.54.4±0.5<0.001
 Mean aortic gradient, mm Hg34±1328±847±12<0.001
 Effective orifice area, cm2 0.94±0.221.04±0.200.74±0.14<0.001
 Doppler stroke volume index, mL/m2 43±1344±1541±100.206
 PP/SVi, mm Hg/mL/m2 1.46±0.571.44±0.561.50±0.600.512
 Zva, mm Hg/mL/m2 4.37±1.254.08±1.204.85±1.19<0.001
 LV stroke work, g-m/bpm159.9±52.7161.3±56.7157.9±44.70.606
  • ARB, angiotensin II receptor blocker; AS, aortic stenosis; BP, blood pressure; LV, left ventricular; PP/SVi, pulse pressure/stroke volume index; Zva, valvuloarterial impedance; bpm, beats per minute.