Baseline characteristics in 172 981 women and men with acute myocardial infarction by age group and symptom presentation
| <65 years* n=58 488 | ≥65 years† n=114 493 | |||
| Without chest pain n=4157 | With chest pain n=54 331 | Without chest pain n=17 834 | With chest pain n=96 659 | |
| Age, years, mean SD | 57.1±6.4 | 55.6±6.8 | 76.3±5.4 | 74.9±5.6 |
| Women, n (%) | 1309 (31.5) | 12 071 (22.2) | 8052 (45.1) | 36 482 (37.7) |
| Risk factors | ||||
| Current smoker, n (%) | 1541 (37.1) | 22 588 (41.6) | 2706 (15.2) | 13 879 (14.4) |
| Diabetes, n (%) | 1359 (32.7) | 9573 (17.6) | 5606 (31.4) | 22 156 (22.9) |
| Hypertension, n (%) | 1741 (41.9) | 17 953 (33.0) | 9235 (51.8) | 46 025 (47.6) |
| Cardiovascular disease history | ||||
| Myocardial infarction, n (%) | 693 (16.7) | 6029 (11.1) | 4689 (26.3) | 23 554 (24.4) |
| Cardiac intervention, n (%) (CABG/PCI) | 420 (10.1) | 4506 (8.3) | 1797 (10.1) | 11 714 (12.1) |
| Heart failure, n (%) | 509 (12.2) | 1699 (3.1) | 4608 (25.8) | 13 065 (13.5) |
| Stroke, n (%) | 368 (8.9) | 2157 (4.0) | 3530 (19.8) | 12 433 (12.9) |
| Medication | ||||
| Aspirin/antiplatelets, n (%) | 1247 (30.0) | 10 743 (19.8) | 7870 (44.1) | 39 732 (41.1) |
| β-blocker, n (%) | 1354 (32.6) | 12 456 (22.9) | 7082 (39.7) | 36 488 (37.7) |
| ACE inhibitor/ARB, % (n) | 1135 (27.3) | 8856 (16.3) | 5729 (32.1) | 23 815 (24.6) |
| Statins, n (%) | 1012 (24.3) | 8802 (16.2) | 3858 (21.6) | 18 861 (19.5) |
| Calcium blocker, n (%) | 533 (12.8) | 5705 (10.5) | 3078 (17.3) | 18 206 (18.8) |
| Diuretics, n (%) | 899 (21.6) | 5053 (9.3) | 7260 (40.7) | 27 679 (28.6) |
| Variables recorded at admission | ||||
| Presence of pulmonary rales, n (%) | 1091 (26.2) | 3817 (7.0) | 7370 (41.3) | 18 914 (19.6) |
| LBBB, n (%) | 281 (6.8) | 1146 (2.1) | 2451 (13.7) | 6806 (7.0) |
| RBBB, n (%) | 86 (2.1) | 634 (1.2) | 611 (3.4) | 2315 (2.4) |
| STEMI, n (%) | 892 (21.5) | 24 617 (45.3) | 2987 (16.7) | 34 815 (36.0) |
| Prehospital CPAP, n (%) | 474 (11.4) | 775 (1.4) | 3233 (18.1) | 3782 (3.9) |
| Delay time, min, median (IQR) | 225 (83–930) | 165 (85–425) | 210 (87–760) | 195 (100–475) |
| Systolic blood pressure, mm Hg, mean (SD) | 143.4±33.3 | 146.6±27.7 | 142.1±33.0 | 147.6±29.3 |
| Heart rate, beats/min, mean (SD) | 92.3±29.4 | 76.4±19.3 | 93.6±28.6 | 78.9±22.4 |
| Troponin I, µ/L, median (IQR) | 2.8 (0.66–11.3) | 5.0 (0.85–24.0) | 3.18 (0.81–11.2) | 4.86 (0.97–22.0) |
| Troponin T, µ/L, median (IQR) | 0.51 (0.18–1.77) | 1.0 (0.26–3.21) | 0.59 (0.20–1.98) | 0.95 (0.26–3.05) |
| Outcomes | ||||
| 30-day mortality, n (%) | 303 (7.3) | 1035 (1.9) | 2928 (16.4) | 8410 (8.7) |
| Per 1000 person-years | 945 | 236 | 2294 | 1140 |
| 1-year mortality, n (%) | 615 (14.8) | 1989 (3.7) | 5830 (32.7) | 16 163 (16.7) |
| Per 1000 person-years | 175 | 39 | 452 | 199 |
| 5-year mortality, n (%) | 1061 (25.5) | 4292 (7.9) | 10 292 (57.7) | 32 899 (34.0) |
| Per 1000 person-years | 83 | 21 | 259 | 109 |
*All p values, when comparing patients <65 years presenting without and with chest pain, <0.001.
†All p values, when comparing patients ≥65 years presenting without and with chest pain, <0.001, except for smoking p=0.0045.
AMI, acute myocardial infarction; ARB, angiotensin receptor blocker; CABG, coronary artery bypass grafting; CPAP, continuous positive airway pressure; LBBB, left bundle branch block; PCI, percutaneous coronary intervention; RBBB, right bundle branch block; STEMI ST, ST-segment-elevation myocardial infarction.