Table 2

Univariable and multivariable predictors of obstructive coronary artery disease in patients with unstable angina

Characteristicsn=979Univariable model,
OR (95% CI)
Multivariable model,
OR (95% CI)
Score
Age >65 years4101.92 (1.49 to 2.49)2.94 (1.97 to 4.41)3
Male gender5781.85 (1.42 to 2.40)2.03 (1.48 to 2.79)2
Prior PCI3821.75 (1.35to 2.26)1.85 (1.21 to 2.81)2
Hypertension*
 13032.79 (1.82 to 4.28)2.26 (1.36 to 3.75)2
 21512.27 (1.40 to 3.69)2.08 (1.20 to 3.61)2
 33723.05 (2.01 to 4.63)2.36 (1.43 to 3.89)2
Current smoker2731.48 (1.06 to 2.06)2.53 (1.70 to 3.77)3
Previous smoker3961.58 (1.17 to 2.14)1.37 (0.97 to 1.95)1
Positive stress test2781.60 (1.21 to 2.11)1.85 (1.34 to 2.56)2
Best CCS grade
 1841.59 (1.01 to 2.51)0.91 (0.54 to 1.56)0
 2912.12 (1.36 to 3.30)1.05 (0.62 to 1.78)0
 3–41074.71 (2.97 to 7.48)1.83 (1.03 to 3.26)2
No variable threshold 2534.03 (2.96 to 5.48)1.96 (1.28 to 2.99)2
Symptoms before admission
 Non-anginal pain2432.50 (1.58 to 3.96)1.89 (1.14 to 3.14)2
 Atypical angina2845.75 (3.67 to 9.01)3.40 (2.01 to 5.75)3
 Typical angina1416.49 (3.90 to 10.8)3.65 (1.99 to 6.69)4
 Missing1453.10 (1.87 to 5.12)2.36 (1.36 to 4.08)2
No palpitations8441.93 (1.26 to 2.94)1.71 (1.07 to 2.74)2
Interaction: prior PCI and age >65 years0.50 (0.28 to 0.91)–2
AUC0.77 (0.74 to 0.80)
  • *(1) Use of antihypertensive drugs and normal blood pressure on admission, (2) high blood pressure on admission, (3) 1+2.

  • †No random variation in the threshold of angina defined by two or more CCS grades.

  • AUC, area under the curve; CCS, Canadian Cardiovascular Society grading of angina pectoris; PCI, percutaneous intervention .