Table 2

Baseline biomarker levels for functional responders and non-responders

	Total cohort=52	Responders=27	Non-responders=22	P values
PINP (ug/L, median, range)	40.0 (15.0–141.0)	43.0 (22.0–141.0)	38.0 (15.0–113.0)	0.53
CTx (ug/L, median, range)	0.40 (0.14–1.14)	0.48 (0.14–1.14)	0.31 (0.16–0.73)	0.07
PIIINP (ug/L, mean±SD)	1.02±0.39	1.09±0.35	0.94±0.43	0.11
MMP-2(ug/L, median, range)	277.3 (155.3–789.5)	258.8 (157.0–789.5)	323.5 (155.3–543.4)	0.13
MMP-9 (ug/L, median, range)	73.5 (13.6–254.1)	71.8 (13.6–254.1)	80.8 (13.6–254.1	0.47
GDF-15 (ug/L, median, range)	2.66 (1.12–10.29)	2.66 (1.12–10.29)	2.75 (1.20–5.95)	0.42
miR-21 (RQ, median, range)	0.8 (0.3–2.4)	0.77 (0.3–1.9)	0.82 (0.5–2.4)	0.72
miR-30d (RQ, median, range)	0.7 (0.2–2.55)	0.81 (0.2–2.55)	0.68 (0.29–2.27)	0.35
miR-122 (RQ, median, range)	0.50 (0.06–3.60)	0.45 (0.08–3.60)	0.69 (0.06–2.48)	0.27
miR-133a (RQ, median, range)	0.78 (0.01–4.52)	0.34 (0.01–4.52)	1.28 (0.01–3.79)	0.08
miR-210 (RQ, median, range)	0.76 (0.03–5.12)	0.57 (0.17–5.12)	0.79 (0.03–3.61)	0.36
miR-486 (RQ, median, range)	0.76 (0.17–3.14)	0.87 (0.17–3.14)	0.73 (0.21–2.48)	0.76

CTx, C-terminal telopeptides; GDF-15, Growth Differentiation Factor-15; MMP-2, matrixmetalloproteinase-2; PINP, N-terminal pro-peptides of collagen I; PIIINP, N-terminal pro-peptides of collagen III; RQ, relative quantity.