Comparison of baseline biomarker expression between with and without >15% reduction in LVESV at 6 months following CRT
| Biomarkers | Responders=12 | Non-responders=16 | P values |
| PINP (ug/L, median, range) | 39.5 (24.0–69.0) | 48.0 (26.0–141.0) | 0.14 |
| CTx (ug/L , median, range) | 0.47 (0.14–1.14) | 0.48 (0.18–0.90) | 0.94 |
| PIIINP (ug/L, mean±SD) | 1.05±0.43 | 1.08±0.46 | 0.87 |
| MMP-2(ug/L , median, range) | 247.5 (155.3–671.5) | 342.5 (194.0–789.5) | 0.05 |
| MMP-9 (ug/L , median, range) | 77.5 (24.7–182.3) | 70.4 (13.6–204.2) | 0.51 |
| GDF-15 (ug/L , median, range) | 1.96 (1.12–4.28) | 2.46 (1.20–10.29) | 0.24 |
| miR-21 (RQ, median, range) | 0.86 (0.50–1.40) | 0.77 (0.60–2.30) | 0.63 |
| miR-30d (RQ, median, range) | 0.64 (0.34–1.68) | 0.91 (0.35–1.86) | 0.39 |
| miR-122 (RQ, median, range) | 0.46 (0.06–3.28) | 0.84 (0.09–3.60) | 0.16 |
| miR-133a (RQ, median, range) | 0.53 (0.01–3.79) | 0.80 (0.08–2.26) | 0.66 |
| miR-210 (RQ, median, range) | 0.42 (0.17–2.05) | 0.85 (0.06–5.12) | 0.15 |
| miR-486 (RQ, median, range) | 0.81 (0.17–1.93) | 0.72 (0.21–2.48) | 0.98 |
CRT, cardiac resynchronisation therapy; CTx, C-terminal telopeptides; GDF-15, Growth Differentiation Factor-15; MMP-2, matrixmetalloproteinase-2; PINP, N-terminal pro-peptides of collagen I; PIIINP, N-terminal pro-peptides of collagen III; RQ, relative quantity.