Table 1

Benefits of copper supplementation in humans

Study populationDose of copperResults
16 healthy young women78 3 or 6 mg of copper sulfate per daySignificant increase in superoxide dismutase activity in red blood cells. Plasminogen activator inhibitor type 1 was significantly reduced (p<0.05) by about 30% after supplementation with 6 mg copper per day. ‘Increased Cu intake could reduce the risk of CVD and atherosclerosis in man by promoting improved fibrinolytic capacity’78
60 patients with stable moderate hypertension87 5 mg of copper sulfate per dayBlood pressure was significantly reduced in those treated with copper (p<0.05) with no significant changes in control patients
It was estimated that 62% of study participants were marginally copper deficient
The study authors concluded that even mild copper deficiency could result in ‘functional alteration in human blood pressure’87
73 hyperlipidemic subjects15 5 mg of copper sulfate per daySignificant decreases in total cholesterol, triglycerides, LDL cholesterol and a slight increment in HDL
38% of the study participants were estimated to be marginally copper deficient
  • CVD, cardiovascular disease; HDL, high-density lipoprotein; LDL, low-density lipoprotein.