Set in heart failure clinic | Telephone contact | Educational component | Predefined treatment protocol | Incorporated relative NP target | Stringent target | Relative NP trigger value | Monitoring more frequently (<every 3 months) | |
Studies not excluding, RR=1 | ||||||||
Anguita et al 14 | ✔ | ✗ | ✗ | ✗ | ✗ | ✔ | ✗ | ✔ |
Felker et al 12 | ✔ | ✗ | ✗ | ✗ | ✗ | ✔ | ✗ | ✔ |
Karlström et al 18 | ✔ | ✗ | ✔ | ✔ | ✗ | ✗ | ✗ | ✔ |
Lainchbury et al 17 | ✗ | ✗ | ✔ | ✗ | ✗ | ✗ | ✗ | ✗ |
Schou et al 20 | ✔ | ✔ | ✔ | ✔ | NA | NA | ✔ | ✔ |
✔ Proportion | 0.80 | 0.20 | 0.6 | 0.40 | 0 | 0.5 | 0.20 | 0.80 |
Studies excluding, RR=1 | ||||||||
Berger et al 15 | ✔ | ✔ | ✔ | ✔ | ✗ | ✗ | ✔ | ✔ |
Januzzi et al 19 | ✔ | ✗ | ✗ | ✗ | ✗ | ✔ | ✗ | ✗ |
Jourdain et al 13 | ✗ | ✗ | ✗ | ✗ | ✗ | ✔ | ✗ | ✗ |
Krupicka et al 16 | ✔ | ✗ | ✗ | ? | ✔ | ✔ | ✗ | ✗ |
Skvortsov et al 21 2015 | ✔ | ✗ | ✗ | ✔ | ✔ | ✔ | ✗ | ✔ |
Troughton et al 3 | ✔ | ✗ | ✗ | ✔ | ✗ | ✗ | ✗ | ✔ |
✔ Proportion | 0.833 | 0.167 | 0.167 | 0.6 | 0.33 | 0.667 | 0.167 | 0.5 |
Proposed new composite intervention | ✔ | ✗ | ✗ | ✔ | ✔ | ✔ | ✗ | – |
Component options for new composite intervention are selected based on the most common option in the ‘more effective’ studies.
NA, not available;NP, natriuretic peptide;RR, relative risk.