All | No premedication | Diazepam | P values* | Midazolam | P values* | Lorazepam | P values* | Oxazepam | P values* | |
Dose | 5 mg/os | 7.5 mg/os | 1 mg /sl | 10 mg/os | ||||||
Tmax | ½ −1½ hour | ½ −1½ hour | 2 hour | 2–3 hours | ||||||
T½ | 20–48 hours | 2–3½ hours | 12–16 hours | 4–15 hours | ||||||
VAS intake | 4.0±2.7 | 3.9±2.6 | 4.1 ± 2.6 | 0.34 | 4.2 ± 2.8 | 0.25 | 4.3 ± 2.7 | 0.05 | 4.0 ± 2.7 | 0.61 |
VAS preprocedure | 4.2±2.7 | 4.1±2.6 | 4.2±2.6 | 0.05 | 4.4±2.8 | 0.25 | 4.5±2.7 | 0.03 | 4.0±2.8 | 0.88 |
VAS postprocedure | 2.5±2.4 | 2.6±2.4 | 2.2±2.3 | 0.03 | 2.4±2.7 | 0.48 | 2.5±2.3 | 0.45 | 2.5±2.5 | 0.65 |
VAS at discharge | 1.6±1.9 | 1.6±1.8 | 1.5±1.8 | 0.71 | 1.4±1.9 | 0.37 | 2.0±2.1 | 0.01 | 1.4±1.7 | 0.17 |
Data are mean±SD. VAS anxiety scores of patients undergoing CAG or PCI (n=1683) at the four different time points split for the different premedication schemes no premedication (n=526), diazepam (n=361), midazolam (n=174), lorazepam (n=361) and oxazepam (n=294).
*P values of VAS anxiety scores in patients with premedication compared with patients without premedication.
CAG, coronary angiograms; PCI, percutaneous coronary interventions; VAS, Visual Analogue Scale.