All | No premedication | Lorazepam | Oxazepam | Diazepam | Midazolam | |
Dose | 1 mg /sl | 10 mg /os | 5 mg /os | 7.5 mg /os | ||
Tmax | 2 hours | 2 – 3 hours | ½ −1½ hour | ½ −1½ hour | ||
T½ | 12 – 16 hours | 4 – 15 hours | 20 – 48 hours | 2 – 3 ½ hours | ||
Demographics | n=1683 | n=526 | n=361 | n=294 | n=327 | n= 174 |
Age (years) | 66±12 | 66±11 | 65±11 | 66±12 | 66±12 | 63±11 |
Male gender | 1159 (69%) | 371 (71%) | 248 (69%) | 199 (68%) | 219 (67%) | 121 (70%) |
BMI | 27±4 | 28±4 | 27±4 | 27±4 | 27±4 | 27±4 |
Level of education | ||||||
Low | 379 (23%) | 119 (23%) | 90 (25%) | 56 (19%) | 73 (22%) | 41 (23%) |
Intermediate | 753 (45%) | 230 (44%) | 158 (44%) | 139 (47%) | 156 (48%) | 70 (40%) |
High | 350 (21%) | 110 (21%) | 79 (22%) | 62 (24%) | 60 (18%) | 39 (22%) |
Unknown | 201 (12%) | 67 (12%) | 34 (9%) | 37 (13%) | 38 (12%) | 24 (14%) |
Medical history | ||||||
Myocardial infarction | 475 (40%) | 166 (43%) | 92 (38%) | 80 (39%) | 80 (36%) | 57 (42%) |
CAG or PCI | 604 (48%) | 195 (49%) | 115 (44%) | 105 (47%) | 120 (51%) | 69 (49%) |
Risk factors | ||||||
Diabetes mellitus | 354 (22%) | 129 (26%) | 73 (21%) | 46 (16%) | 69 (22%) | 37 (22%) |
Known hypertension | 860 (53%) | 275 (55%) | 184 (52%) | 153 (53%) | 157 (49%) | 91 (54%) |
Family history of CHD | 1045 (64%) | 318 (64%) | 230 (65%) | 179 (62%) | 199 (62%) | 119 (70%) |
Hypercholesterolemia | 718 (44%) | 226 (45%) | 165 (46%) | 105 (36%) | 125 (39%) | 97 (57%) |
Current cigarette smoking | 301 (18%) | 93 (18%) | 65 (18%) | 53 (18%) | 57 (17%) | 33 (19%) |
Urgency and treatment | ||||||
Elective CAG or PCI | 1625 (97%) | 501 (95%) | 346 (96%) | 285 (97%) | 321 (98%) | 171 (98%) |
Femoral artery approach | 796 (48%) | 225 (44%) | 179 (50%) | 149 (52%) | 161 (50%) | 82 (48%) |
CAG | 628 (37%) | 202 (38%) | 128 (36%) | 107 (36%) | 135 (41%) | 56 (32%) |
PCI | 1055 (63%) | 324 (62%) | 233 (65%) | 187 (64%) | 192 (59%) | 118 (68%) |
Number of grafts | 1.2±1.0 | 1.2±1.0 | 1.2±0.8 | 1.2±1.0 | 1.0±0.8 | 1.3±0.9 |
Procedure time (minutes) | 45±25 | 45±24 | 44±27 | 46±26 | 44±26 | 43±22 |
Follow-up | ||||||
1 years mortality | 58 (4%) | 23 (5%) | 11 (3%) | 10 (4%) | 10 (3%) | 4 (3%) |
5 years mortality | 191 (14%) | 70 (16%) | 33 (11%) | 41 (17%) | 34 (13%) | 12 (8%) |
Data are expressed as number (%), mean±SD.
BMI, body mass index; CAG, coronary angiography; CHD, coronary heart disease; PCI, percutaneous coronary interventions.