Table 3

Diagnostic accuracy by ROC and univariate, unadjusted survival analysis by Cox proportional regression

ParametersAUC by ROC
(95% CI)
Optimal cut-offHR95% CIχ2
Age, years0.51† (0.35 to 0.67)>721.3†0.79 to 2.1
Sex0.65† (0.49 to 0.81)Male2.7†(0.05) 1.0 to 7.24.2†(0.054)
Heart rate, /min0.70* (0.56 to 0.84)>801.8*1.0 to 7.25.7*
Haemoglobin, g/dL0.56† (0.39 to 0.74)≥14.41.4†0.9 to 2.3
WHO FC0.60† (0.46 to 0.75)>II1.7†(0.086) 0.9 to 3.33.6†(0.071)
6MWT, m0.66† (0.51 to 0.80)<3301.8†(0.081) 0.9 to 3.63.4†(0.064)
NTproBNP, pg/mL0.67* (0.59 to 0.91)≥41402.8***1.6 to 4.818.2***
cTnT, ng/L0.63† (0.51 to 0.87)≥282.1**1.2 to 3.78.6**
LV-EF, %0.70* (0.54 to 0.86)>752.1**1.2 to 3.59.2**
RA-ESABSA, cm2/m2 0.68* (0.50 to 0.85)≥151.7*1.0 to 2.94.7*
RV-EDD, mm0.68* (0.51 to 0.85)>482.1**1.3 to 3.47.8**
TAPSE, mm0.71* (0.55 to 0.88)<162.3**1.3 to 3.910.2**
RV-FAC, %0.61† (0.43 to 0.78)<221.7†0.8 to 11.4
RV-ASI, %0.69* (0.52 to 0.87)<371.7* 1.5 to 2.84.4*
LV-EI0.68** (0.51 to 0.86)≥1.72.5**1.5 to 4.211.9***
TASV, cm/s0.51† (0.33 to 0.68)<101.2†0.7 to 2.0
Tei-Index0.56† (0.39 to 0.73)≥0.721.1†0.6 to 1.7
RV-2Dstrain, −%0.78** (0.62 to 0.90)≤│12│2.3**1.4 to 3.910.5***
RV-MMI, mm Hg*%0.85*** (0.76 to 0.95)≤0.313.3**1.6 to 7.016.0***
ESC/ERS PAH risk score0.64† (0.49 to 0.79)>10%1.9*1.0 to 3.54.4*
  • *P<0.05, **P<0.01, ***P<0.001.

  • †Not significant.

  • 6MWT, 6 min walk test; ASI, automated systolic index; AUC, area under the curve; BSA, body surface area; cTnT cardiac troponin T; EDD, end-diastolic diameter; ERS, European Respiratory Society; ESC, European Society of Cardiology; FAC, fractional area change; FC, functional class; LV-EF, left ventricular ejection fraction; LV-EI, left ventricular eccentricity index; NTproBNP, N-terminal pro-brain natriuretic peptide; PAH, pulmonary arterial hypertension; RA-ESA, right atrial end-systolic area; ROC, receiver operating characteristics; RV, right ventricular; RV-2Dstrain, two-dimensional strain; RV-MMI, right ventricular myo-mechanical index; TAPSE, tricuspid annular plane systolic excursion; TASV, tricuspid annular systolic velocity.