Standard predictors | Single predictor examined in the model(stratified by centre) | All standard predictors in the model(stratified by centre) | ||||
HR | 95% CI of HR | P values | HR | 95% CI of HR | P values | |
Demographics and history | ||||||
Sex (male=1) | 1.004 | 0.889 to 1.134 | 0.95 | 1.150 | 1.005 to 1.315 | 0.042 |
Age/year | 1.024 | 1.013 to 1.034 | <0.0001 | 1.013 | 1.001 to 1.025 | 0.030 |
Age.time*/year.year | 1.00374 | 1.002 to 1.006 | 0.0004 | 1.004 | 1.002 to 1.006 | <0.0001 |
Smoking status (ex-smoker compared with never smoking) | 1.203 | 1.026 to 1.410 | 0.0062 | 1.210 | 1.025 to 1.428 | <0.0001 |
Smoking status (smoking compared with never smoking) | 1.309 | 1.110 to 1.545 | 1.547 | 1.300 to 1.842 | ||
Hypertension, Y/N | 1.105 | 0.985 to 1.239 | 0.090 | 0.991 | 0.870 to 1.129 | 0.89 |
Diabetes, Y/N | 1.318 | 1.133 to 1.533 | 0.0003 | 1.261 | 1.076 to 1.480 | 0.0043 |
Previous AMI, Y/N | 1.169 | 1.033 to 1.324 | 0.014 | 1.151 | 1.012 to 1.308 | 0.032 |
Current medication | ||||||
Aspirin, Y/N | 0.978 | 0.820 to 1.165 | 0.80 | 1.021 | 0.852 to 1.225 | 0.82 |
Beta-blocker, Y/N | 1.010 | 0.893 to 1.141 | 0.88 | 1.013 | 0.888 to 1.155 | 0.85 |
Calcium antagonist, Y/N | 1.232 | 1.095 to 1.385 | 0.0005 | 1.121 | 0.982 to 1.279 | 0.090 |
ACE inhibitor, Y/N | 1.246 | 1.099 to 1.412 | 0.0006 | 1.054 | 0.916 to 1.213 | 0.46 |
Long-lasting nitrate, Y/N | 1.738 | 1.527 to 1.978 | <0.0001 | 1.348 | 1.172 to 1.551 | <0.0001 |
Diuretics, Y/N | 1.613 | 1.437 to 1.810 | <0.0001 | 1.180 | 1.030 to 1.352 | 0.017 |
Digoxin, Y/N | 2.212 | 1.805 to 2.711 | <0.0001 | 1.576 | 1.269 to 1.957 | <0.0001 |
Statins, Y/N | 0.746 | 0.663 to 0.839 | <0.0001 | 0.883 | 0.769 to 1.014 | 0.077 |
Antiarrhythmic drugs, Y/N | 1.119 | 0.763 to 1.642 | 0.56 | 0.924 | 0.627 to 1.362 | 0.69 |
Biochemical predictors | ||||||
Log(CRP/mg/L) | 1.171 | 1.113 to 1.232 | <0.0001 | 1.070 | 1.014 to 1.480 | 0.014 |
ApoA1/mg/dL | 0.905 | 0.764 to 1.072 | 0.25 | 0.707 | 0.516 to 0.969 | 0.031 |
Log(ApoB/mg/dL) | 1.165 | 0.938 to 1.447 | 0.17 | 0.826 | 0.413 to 1.651 | 0.59 |
Chol-HDL/mmol/L | 0.954 | 0.794 to 1.147 | 0.62 | 1.104 | 0.714 to 1.708 | 0.66 |
Chol-LDL/mmol/L | 1.027 | 0.948 to 1.112 | 0.52 | 0.912 | 0.751 to1.107 | 0.35 |
Log (cholesterol/mmol/L) | 1.247 | 0.940 to 1.654 | 0.13 | 1.786 | 0.577 to 5.525 | 0.31 |
Log (triglycerides/mmol/L) | 1.024 | 0.919 to 1.141 | 0.67 | 1.030 | 0.878 to 1.208 | 0.72 |
Glomerular filtration rate (GFR/mL/min) | 0.985 | 0.982 to 0.988 | <0.0001 | 0.995 | 0.991 to 0.999 | 0.0084 |
*Time is years since randomisation.
AMI, acute myocardial infarction; Chol, cholesterol; CRP, C-reactive protein; HDL, high-density lipoprotein; LDL, low-density lipoprotein; N, hypertension is not present; Y, hypertension is present.