Table 2

Composite outcome including acute myocardial infarction, unstable angina pectoris, cerebrovascular disease and all-cause death. HRs of standard predictors when used alone and when used in combination with the rest of the standard predictors

Standard predictorsSingle predictor examined in the model(stratified by centre)All standard predictors in the model(stratified by centre)
HR95% CI of HRP valuesHR95% CI of HRP values
Demographics and history
Sex (male=1)1.0040.889 to 1.1340.951.1501.005 to 1.3150.042
Age/year1.0241.013 to 1.034<0.00011.0131.001 to 1.0250.030
Age.time*/year.year1.003741.002 to 1.0060.00041.0041.002 to 1.006<0.0001
Smoking status (ex-smoker compared with never smoking)1.2031.026 to 1.4100.00621.2101.025 to 1.428<0.0001
Smoking status (smoking compared with never smoking)1.3091.110 to 1.5451.5471.300 to 1.842
Hypertension, Y/N1.1050.985 to 1.2390.0900.9910.870 to 1.1290.89
Diabetes, Y/N1.3181.133 to 1.5330.00031.2611.076 to 1.4800.0043
Previous AMI, Y/N1.1691.033 to 1.3240.0141.1511.012 to 1.3080.032
Current medication
Aspirin, Y/N0.9780.820 to 1.1650.801.0210.852 to 1.2250.82
Beta-blocker, Y/N1.0100.893 to 1.1410.881.0130.888 to 1.1550.85
Calcium antagonist, Y/N1.2321.095 to 1.3850.00051.1210.982 to 1.2790.090
ACE inhibitor, Y/N1.2461.099 to 1.4120.00061.0540.916 to 1.2130.46
Long-lasting nitrate, Y/N1.7381.527 to 1.978<0.00011.3481.172 to 1.551<0.0001
Diuretics, Y/N1.6131.437 to 1.810<0.00011.1801.030 to 1.3520.017
Digoxin, Y/N2.2121.805 to 2.711<0.00011.5761.269 to 1.957<0.0001
Statins, Y/N0.7460.663 to 0.839<0.00010.8830.769 to 1.0140.077
Antiarrhythmic drugs, Y/N1.1190.763 to 1.6420.560.9240.627 to 1.3620.69
Biochemical predictors
Log(CRP/mg/L)1.1711.113 to 1.232<0.00011.0701.014 to 1.4800.014
ApoA1/mg/dL0.9050.764 to 1.0720.250.7070.516 to 0.9690.031
Log(ApoB/mg/dL)1.1650.938 to 1.4470.170.8260.413 to 1.6510.59
Chol-HDL/mmol/L0.9540.794 to 1.1470.621.1040.714 to 1.7080.66
Chol-LDL/mmol/L1.0270.948 to 1.1120.520.9120.751 to1.1070.35
Log (cholesterol/mmol/L)1.2470.940 to 1.6540.131.7860.577 to 5.5250.31
Log (triglycerides/mmol/L)1.0240.919 to 1.1410.671.0300.878 to 1.2080.72
Glomerular filtration rate (GFR/mL/min)0.9850.982 to 0.988<0.00010.9950.991 to 0.9990.0084
  • *Time is years since randomisation.

  • AMI, acute myocardial infarction; Chol, cholesterol; CRP, C-reactive protein; HDL, high-density lipoprotein; LDL, low-density lipoprotein; N, hypertension is not present; Y, hypertension is present.