HRs (95% CI) for the prospective association between BMI and first CVD events
| N | CVD events | HR (95% CI)* | HR (95% CI)† | |
| European men | ||||
| BMI categories | ||||
| <18.5 | 333 | 25 | 1.94 (1.31 to 2.89) | 1.97 (1.33 to 2.94) |
| 18.5–24.9 | 20 534 | 782 | 1.00 (ref) | 1.00 (ref) |
| 25–29.9 | 44 361 | 1936 | 1.11 (1.02 to 1.21) | 0.99 (0.91 to 1.08) |
| 30+ | 29 498 | 1622 | 1.45 (1.33 to 1.58) | 1.06 (0.97 to 1.15) |
| Missing | 32 010 | 890 | ||
| Total | 126 736 | 5255 | ||
| BMI as continuous (per five unit increase) | 1.13 (1.10 to 1.15) | 1.04 (1.01 to 1.07) | ||
| BMI as continuous (per five unit increase) from BMI 18.5 | 1.13 (1.07 to 1.16) | 1.04 (1.02 to 1.07) | ||
| Indian men | ||||
| BMI categories | ||||
| <18.5 | 129 | 6 | 1.13 (0.50 to 2.54) | 1.37 (0.61 to 3.07) |
| 18.5–24.9 | 5528 | 237 | 1.00 (ref) | 1.00 (ref) |
| 25–29.9 | 8044 | 342 | 1.03 (0.87 to 1.22) | 0.92 (0.78 to 1.08) |
| 30+ | 3193 | 168 | 1.34 (1.10 to 1.64) | 1.09 (0.89 to 1.32) |
| Missing | 3310 | 49 | ||
| Total | 20 210 | 802 | ||
| BMI as continuous (per five unit increase) | 1.17 (1.09 to 1.24) | 1.09 (1.01 to 1.17) | ||
| BMI as continuous (per five unit increase) from BMI 18.5 | 1.17 (1.10 to 1.25) | 1.09 (1.02 to 1.18) | ||
| European women | ||||
| BMI categories | ||||
| <18.5 | 889 | 52 | 2.39 (1.80 to 3.18) | 2.62 (1.97 to 3.48) |
| 18.5–24.9 | 22 864 | 574 | 1.00 (ref) | 1.00 (ref) |
| 25–29.9 | 23 524 | 751 | 1.11 (0.99 to 1.24) | 0.98 (0.88 to 1.10) |
| 30+ | 21 464 | 845 | 1.46 (1.31 to 1.62) | 1.02 (0.92 to 1.14) |
| Missing | 26 606 | 628 | ||
| Total | 95 347 | 2850 | ||
| BMI as continuous (per five unit increase) | 1.13 (1.09 to 1.16) | 1.00 (0.97 to 1.03) | ||
| BMI as continuous (per five unit increase) from BMI 18.5 | 1.15 (1.12 to 1.18) | 1.02 (0.99 to 1.06) | ||
| Indian women | ||||
| BMI categories | ||||
| <18.5 | 104 | 3 | 1.21 (0.38 to 3.85) | 1.83 (0.57–5.83) |
| 18.5–24.9 | 3319 | 60 | 1.00 (ref) | 1.00 (ref) |
| 25–29.9 | 4805 | 142 | 1.50 (1.11 to 2.03) | 1.44 (1.07 to 1.95) |
| 30+ | 3534 | 128 | 1.85 (1.36 to 2.52) | 1.61 (1.18 to 2.18) |
| Missing | 2411 | 21 | ||
| Total | 14 173 | 354 | ||
| BMI as continuous (per five unit increase) | 1.15 (1.06 to 1.25) | 1.09 (0.99 to 1.19) | ||
| BMI as continuous (per five unit increase) from BMI 18.5 | 1.15 (1.06 to 1.25) | 1.09 (1.00 to 1.19) |
*Adjusted for age.
†Adjusted for Framingham risk score.
BMI, body mass index; CVD, cardiovascular disease.