Table 2

Overview of key prospective registries for stroke prevention in patients with AF and treatment of VTE

Registry	Design	Objective
GARFIELD-AF69	International, multicentre registry; target n=55 000 patients at >1000 centres in 50 countries.	To assess treatment management and outcomes in patients with newly diagnosed AF and one or more additional risk factors for stroke.
ORBIT AF I70	Multicentre outpatient registry in the USA of over 10 000 patients.	To assess current practice patterns, adherence and resource use in patients with AF and the adoption and impact of NOACs.
ORBIT AF II43 February 2013–ongoing	Multicentre outpatient registry targeting 15 000 patients in 300 US practices with newly diagnosed AF and/or with AF who recently transitioned to NOAC treatment.	To assess the clinical status, outcomes (major adverse cardiovascular events, bleeding) and management of anticoagulation, as well as the use of NOACs.
GLORIA-AF71	International, multicentre registry; target n=56 000 patients at ≤2200 sites in <50 countries.	To characterise patients with newly diagnosed AF at risk of stroke in various regions of the world; to describe antithrombotic treatment patterns; to collect data on the effectiveness and safety of NOACs compared with VKAs.
PREFER in AF registry72	Multicentre registry in 7 European countries; n=7243 patients enrolled from 461 centres.	To gain insight into the characteristics and management of patients with AF.
Dresden NOAC Registry39	Registry of patients treated with NOACs in private practices and hospitals in the Saxony region of Germany.	To collect data on the effectiveness, safety and management of NOAC therapy in daily care.
RIETE 2001–ongoing73	International, multicentre registry of patients with VTE.	To evaluate outcomes in patients with VTE.
GARFIELD-VTE March 2014–ongoing74	International multicentre registry; target n=10 000 patients from ~500 sites in 28 countries.	To assess the duration of anticoagulation management and clinical and economic outcomes in patients with acute VTE in the real-world setting.
PREFER in VTE registry75	Multicentre registry in 7 European countries; n=3545 patients enrolled from 381 centres.	To assess the management of patients with VTE, use of healthcare resources and costs of treatment in patients diagnosed with VTE in hospitalised or specialist centres across Europe.
SWIVTER44	Swiss multicentre registry.	To evaluate outcomes in patients with VTE.

AF, atrial fibrillation; GARFIELD-AF, Global Anticoagulant Registry in the FIELD-Atrial Fibrillation; GARFIELD-VTE, Global Anticoagulant Registry in the FIELD-Venous Thromboembolism; GLORIA-AF, Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation; NOAC, non-vitamin K antagonist oral anticoagulant; ORBIT AF, Outcomes Registry for Better Informed Treatment of Atrial Fibrillation; PREFER in AF, PREvention oF thromboembolic events — European Registry in Atrial Fibrillation; PREFER in VTE, PREvention oF thromboembolic events — European Registry in Venous Thromboembolism; RIETE, Registro Informatizado de Pacientes con Enfermedad TromboEmbólica; SWIVTER, SWIss Venous ThromboEmbolism Registry; VKA, vitamin K antagonist; VTE, venous thromboembolism.