Comparison of NT-proBNP (ng/L) between the groups
| Time point | AS (SAVR) n=199 | AS+CABG (SAVR) n=75 | P value* | AR (SAVR) n=42 | P value* | AS (TAVI) n=126 | P value* | P value between groups† |
| Enrolment | 380 (180–920) | 570 (245–1125) | 0.83 | 270 (200–860) | >0.99 | 1790 (780–4260) | <0.001 | <0.001 |
| Index‡ | 0.36 (0.19–0.96) | 0.51 (0.18–0.99) | >0.99 | 0.46 (026–0.73) | >0.99 | 1.13 (0.50–2.83) | <0.001 | <0.001 |
| Preoperative | 430 (170–1030) | 730 (260–1770) | 0.47 | 215 (110–640) | 0.26 | 2030 (1030–4960) | <0.001 | <0.001 |
| Index‡ | 0.38 (0.18–0.99) | 0.54 (0.18–1.12) | >0.99 | 0.32 (0.13–0.62) | >0.99 | 1.33 (0.73–3.02) | <0.001 | <0.001 |
| Postoperative day 1 | 2545 (1575–3940) | 3245 (1915–4730) | 0.39 | 1515 (1015–2295) | 0.001 | 3340 (1770–5320) | 0.11 | <0.001 |
| Index‡ | 2.38 (1.68–3.64) | 2.42 (1.69–2.68) | >0.99 | 1.94 (1.54–2.75) | >0.99 | 2.13 (1.15–3.44) | 0.49 | 0.17 |
| Postoperative day 3/4 | 3800 (2580–6520) | 4675 (2780–7910) | 0.81 | 2670 (1420–4150) | 0.007 | 3050 (1350–6070) | 0.002 | <0.001 |
| Index‡ | 3.74 (2.59–5.46) | 3.87 (2.23–5.91) | >0.99 | 3.09 (2.08–5.23) | >0.99 | 1.82 (0.82–3.18) | <0.001 | <0.001 |
| 6-month follow-up | 300 (170–650) | 470 (250–820) | 0.47 | 215 (100–600) | >0.99 | 1185 (480–2175) | <0.001 | <0.001 |
| Index‡ | 0.29 (0.17–0.54) | 0.42 (0.17–0.64) | >0.99 | 0.34 (0.15–0.60) | >0.99 | 0.80 (0.37–1.37) | <0.001 | <0.001 |
Values are given as median (25th to 75th percentile).
*Multiple comparisons of mean ranks for all groups P value (2-tailed), post hoc comparisons of mean ranks of all pairs of groups, P values after each variable display comparison with AS (SAVR) group.
†Kruskal-Wallis test for comparison of the subgroups.
‡The ratio of NT-proBNP to the reference NT-proBNP value for age; 450 ng/L for >50 years, 900 ng/L for 50–75 years and 1800 ng/L for >75 years.
AR, aortic regurgitation; AS, aortic stenosis; CABG, coronary artery bypass grafting; NT-proBNP, N-terminal pro-B-type natriuretic peptide; SAVR, surgical aortic valve replacement; TAVI, transcatheter aortic valve intervention.