Differences between infections after initial implantation and repeat reoperation
| Initial implantation (n=178) | Reoperation (n=254) | P values | |
| Localised pocket infection | 87 (48.9 %) | 178 (70.1 %) | <0.001 |
| Lead-associated endocarditis | 92 (51.7 %) | 120 (47.3 %) | 0.363 |
| Cryptogenic blood stream infection | 46 (25.8 %) | 61 (24 %) | 0.734 |
| Total number of leads in place (SD) | 2.0±0.6 | 2.5±0.9 | <0.001 |
| Median implant duration (IQR) | 21.1 (2.9, 47.2) | 71 (32.5, 113.2) | <0.001 |
| Median time from last procedure until infection (IQR) | 8.9 (0.9, 33.3) | 19.5 (1.1, 62.9) | <0.0001 |
| Excision requiring laser sheath | 47 (26.4 %) | 166 (65.6 %) | <0.001 |
| Fever >38°C | 89 (50 %) | 115 (45.3 %) | 0.378 |
| New moderate or severe valve regurgitation | 33 (19.5 %) | 29 (12.3 %) | 0.05 |
| Sepsis | 55 (30.9 %) | 49 (19.3 %) | 0.006 |
| Pain at pocket site | 58 (32.6 %) | 125 (49.2 %) | 0.001 |
| Warmth at pocket site | 45 (25.3 %) | 91 (35.8 %) | 0.021 |
| Pus from pocket site | 35 (19.7 %) | 80 (31.5 %) | 0.008 |
| Drainage from pocket | 49 (27.5 %) | 100 (39.4 %) | 0.013 |
| Skin ulceration at pocket site | 17 (9.6 %) | 36 (14.2 %) | 0.18 |
| Skin erosion at pocket site | 29 (16.3 %) | 61 (24 %) | 0.055 |
| Metastatic foci of infection | 30 (16.9 %) | 22 (8.7 %) | 0.016 |
| Stigmata of endocarditis | 4 (2.2 %) | 11 (4.3 %) | 0.295 |
| Mean C-reactive protein, mg/dL (SD) | 28.3±37.06 | 35.8±39.4 | 0.1 |
| Mean erythrocyte sedimentation rate, mm/hour (SD) | 41.8±34.1 | 34.7±28.0 | 0.42 |
| Mean leucocyte count (×10^9L) (SD) | 10.5±5.1 | 9.5±5.4 | 0.025 |