Table 3

Sub-hazard ratios (95% CI) for MI/IHD, stroke and congestive heart failure per third of each biomarker distribution in a competing risk model for 1112 fasting men with no CVD at entry and complete covariate data

BiomarkerMI/IHDStrokeCongestive Heart failure
Sub-hazard ratio (95% CI)Sub-hazard ratio (95% CI)Sub-hazard ratio (95% CI)
Troponin1.30 (1.07 to 1.59)0.83 (0.64 to 1.06)1.84 (1.21 to 2.80)
BNP1.10 (0.91 to 1.33)1.33 (1.04 to 1.70)1.94 (1.26 to 2.97)
CRP1.10 (0.90 to 1.35)1.01 (0.80 to 1.28)1.00 (0.71 to 1.41)
IL-60.94 (0.78 to 1.14)1.14 (0.91 to  1.42)0.84 (0.57 to 1.22)
IL-6 receptor1.02 (0.84 to 1.23)0.92 (0.72 to 1.16)1.04 (0.74 to 1.47)
Cholesterol1.55 (1.27 to 1.88)0.89 (0.72 to 1.10)1.13 (0.78 to 1.63)
Triglyceride1.08 (0.88 to 1.33)1.01 (0.81 to 1.25)0.77 (0.54 to 1.10)
Lp-a1.35 (1.12 to 1.63)0.90 (0.71 to 1.13)0.69 (0.45 to 1.04)
VCAM-10.90 (0.75 to 1.10)1.05 (0.84 to 1.32)1.28 (0.88 to 1.86)
E-selectin0.88 (0.73 to 1.07)1.17 (0.93 to  1.47)1.16 (0.79 to 1.69)
Alkaline phosphatase0.92 (0.76 to 1.11)1.22  (0.98 to  1.51)0.92 (0.65 to 1.33)
Aspartate transaminase0.83 (0.69 to 1.00)0.77  (0.61 to  0.98)1.31 (0.91 to 1.84)
Alanine transaminase0.96 (0.79 to 1.18)0.99  (0.79 to  1.25)1.00 (0.70 to 1.43)
Gamma-GT0.89 (0.73 to 1.09)1.00 (0.79 to 1.26)0.98 (0.71 to 1.34)
Glutamate dehydrogenase1.00 (0.78 to 1.32)1.07  (0.77 to  1.49)1.11 (0.66 to 1.85)
White cell count1.20 (1.00 to 1.45)1.20 (0.93 to 1.53)1.13 (0.75 to 1.70)
Viscosity1.12 (0.93 to 1.35)1.13 (0.90 to 1.41)1.21 (0.84 to 1.75)
Fibrinogen1.16 (0.96 to 1.39)1.11 (0.89 to 1.37)0.95 (0.65 to 1.38)
Ferritin0.94 (0.79 to 1.13)1.02 (0.81 to  1.28)1.33 (0.88 to 2.01)
GDF-150.95 (0.77 to 1.17)0.94 (0.74 to 1.21)1.08 (0.71 to 1.66)
PAPP-A1.02 (0.84 to 1.23)1.14 (0.91 to 1.44)1.41 (1.00 to 1.97)
Cystatin1.01 (0.83 to 1.23)1.14 (0.90 to 1.45)1.01 (0.66 to 1.53)
Creatinine0.85 (0.70 to 1.02)0.89 (0.71 to 1.12)1.21 (0.80 to 1.82)
Glucose1.09 (0.88 to 1.34)1.12 (0.88 to 1.42)1.07 (0.76 to 1.49)
RBP-40.93 (0.77 to 1.11)0.84 (0.66 to 1.07)0.82 (0.58 to 1.17)
Fetuin-A1.03 (0.86 to 1.24)1.11 (0.88 to 1.41)1.31 (0.94 to 1.82)
Uric acid0.94 (0.78 to 1.13)1.04 (0.81 to 1.33)1.19 (0.83 to 1.71)
Vitamin B61.00 (0.82 to 1.21)0.96 (0.76 to 1.21)1.12 (0.79 to 1.57)
  • Results in bold are significant (P<0.01).

  • Adjusted for covariates: age, smoking, diabetes, systolic blood pressure, total cholesterol, total triglycerides, body mass index and family history of premature CHD.

  • BNP, B-type natriuretic peptide; CHD, coronary heart disease; CRP, C reactive protein;  CVD,  cardiovascular disease; GDF-15, growth differentiation factor-15;  IHD, ischaemic heart disease; IL, interleukin; Lp-a, lipoprotein-a; MI, myocardial infarction; PAPP-A, pregnancy- associated plasma protein-A; RBP-4, retinol binding protein-4;  VCAM-1, vascular cell adhesion molecule-1.