Relationship between molecules and clinicopathological features
| Preoperative BNP (pg/mL) | P value | Preoperative NT-proBNP (pg/mL) | P value | HIF-2 alpha | P value | Preoperative VEGF (pg/mL) | P value | |
| Mean±SD | Mean±SD | Mean±SD | Mean±SD | |||||
| All patients (n=129) | 44.2±47.9 | 227.5±261.5 | 5.1±4.9 | 173.1±211.9 | ||||
| Karnofsky performance status | ||||||||
| >80% (n=93) | 40.3±50.0 | 4E-04 | 198.2±265.4 | 4E-04 | 3.3±4.0 | <0.0001 | 124.3±164.8 | <0.0001 |
| <80% (n=36) | 56.3±38.7 | 321.2±234.6 | 7.6±4.2 | 364.1±256.1 | ||||
| Hypertension, arrhythmia or diabetes mellitus | ||||||||
| Positive (n=71) | 37.2±42.4 | 0.018 | 190.9±221.1 | 0.035 | 4.1±3.6 | 0.3496 | 157.6±183.8 | 0.0946 |
| Negative (n=58) | 52.5±53.4 | 267.2±302.5 | 5.2±5.2 | 212.5±189.4 | ||||
| Grade | ||||||||
| 1 (n=10) | 23.4±25.7 | 0.015 | 129.0±90.5 | 0.013 | 2.4±2.6 | <0.0001 | 40.9±38.3 | <0.0001 |
| 2 (n=63) | 36.8±43.9 | 164.9±208.6 | 3.0±2.5 | 102.2±119.6 | ||||
| 2 (n=47) | 57.1±54.3 | 297.2±300.3 | 7.3±12.2 | 333.7±248.6 | ||||
| 4 (n=9) | 63.1±49.2 | 382.1±352.8 | 11.7±3.0 | 566.6±123.8 | ||||
| pT | ||||||||
| 1/2 (n=59) | 28.9±33.2 | 2E-04 | 113.7±79.5 | <0.0001 | 2.6±2.3 | <0.0001 | 84.0±95.3 | 0.0005 |
| 3/4 (n=70) | 55.7±53.9 | 315.2±316.9 | 6.4±5.1 | 291.6±251.3 | ||||
| Distant metastasis (M) | ||||||||
| M0 (n=80) | 34.7±44.7 | <0.0001 | 174.4±254.9 | <0.0001 | 3.6±3.7 | 0.0002 | 139.7±193.2 | <0.0001 |
| M1 (n=49) | 60.1±49.2 | 327.4±250.8 | 6.5±5.2 | 277.0±234.5 |
BNP, brain natriuretic peptide; HIF-2, hypoxia-inducible factor 2; NT-proBNP, N-terminal pro-BNP; VEGF, vascular endothelial growth factor.