Table 1

Relationship between molecules and clinicopathological features

Preoperative BNP (pg/mL)P valuePreoperative NT-proBNP (pg/mL)P valueHIF-2 alphaP valuePreoperative VEGF (pg/mL)P value
Mean±SDMean±SDMean±SDMean±SD
All patients (n=129)44.2±47.9227.5±261.55.1±4.9173.1±211.9
Karnofsky performance status
 >80% (n=93)40.3±50.04E-04198.2±265.44E-043.3±4.0<0.0001124.3±164.8<0.0001
 <80% (n=36)56.3±38.7321.2±234.67.6±4.2364.1±256.1
Hypertension, arrhythmia or diabetes mellitus
 Positive (n=71)37.2±42.40.018190.9±221.10.0354.1±3.60.3496157.6±183.80.0946
 Negative (n=58)52.5±53.4267.2±302.55.2±5.2212.5±189.4
Grade
 1 (n=10)23.4±25.70.015129.0±90.50.0132.4±2.6<0.000140.9±38.3<0.0001
 2 (n=63)36.8±43.9164.9±208.63.0±2.5102.2±119.6
 2 (n=47)57.1±54.3297.2±300.37.3±12.2333.7±248.6
 4 (n=9)63.1±49.2382.1±352.811.7±3.0566.6±123.8
pT
 1/2 (n=59)28.9±33.22E-04113.7±79.5<0.00012.6±2.3<0.000184.0±95.30.0005
 3/4 (n=70)55.7±53.9315.2±316.96.4±5.1291.6±251.3
Distant metastasis (M)
 M0 (n=80)34.7±44.7<0.0001174.4±254.9<0.00013.6±3.70.0002139.7±193.2<0.0001
 M1 (n=49)60.1±49.2327.4±250.86.5±5.2277.0±234.5
  • BNP, brain natriuretic peptide; HIF-2, hypoxia-inducible factor 2; NT-proBNP, N-terminal pro-BNP; VEGF, vascular endothelial growth factor.