Cox regression analysis for various potential prognostic factors in overall survival after nephrectomy
| Variable | Unfavourable/favourable factors | Number of patients | Univariate (U) | Multivariate (M) | ||||
| Relative risk | 95% CI | P value | Relative risk | 95% CI | P value | |||
| Pre-BNP | High/low | 64/65 | 3.835 | 1.794 to 8.196 | 0.0005 | 1.429 | 0.416 to 14.179 | 0.8407 |
| Pre-NT-proBNP | High/low | 64/65 | 3.168 | 1.329 to 7.553 | 0.0093 | 1.221 | 0.280 to 8.746 | 0.9022 |
| HIF-2 alpha | High/low | 64/65 | 6.764 | 3.185 to 14.365 | <0.0001 | 1.146 | 0.390 to 10.076 | 0.9161 |
| Pre-VEGF | High/low | 64/65 | 6.04 | 2.667 to 13.680 | <0.0001 | 3.974 | 0.396 to 39.929 | 0.2411 |
| Grade | 4/3/2/1 | 9/47/63/10 | 4.438 | 2.839 to 6.939 | <0.0001 | 11.061 | 2.337 to 52.346 | 0.0024 |
| pT | 4,3/2,1 | 58/71 | 8.061 | 3.083 to 21.071 | 0.0009 | 1.248 | 0.286 to 10.530 | 0.8107 |
| Metastasis | 1/0 | 49/80 | 8.722 | 4.025 to 18.901 | 0.0010 | 3.019 | 0.939 to 9.710 | 0.0638 |
| Post-BNP | High/low | 64/65 | 3.678 | 1.620 to 8.348 | 0.0018 | 6.952 | 0.585 to 82.650 | 0.1247 |
| Post-NT-proBNP | High/low | 64/65 | 2.126 | 0.946 to 4.774 | 0.0677 | 1.228 | 0.152 to 10.223 | 0.8137 |
| Post-VEGF | High/low | 64/65 | 8.394 | 3.984 to 17.692 | <0.0001 | 1.182 | 0.176 to 12.730 | 0.889 |
BNP, brain natriuretic peptide; HIF-2, hypoxia-inducible factor 2; NT-proBNP, N-terminal pro-BNP; VEGF, vascular endothelial growth factor.