Table 4

Multivariate analysis of mortality according to management strategy

VariableIn-hospital mortality1-year mortality
 HR95% CIP valueHR95% CIP value
Surgical patients
 Age (years)1.041.00 to 1.080.03
 EuroSCORE II1.001.00 to 1.010.28
 Serum eGFR (mL/min)*0.980.96 to 0.990.005
 Serum haemoglobin (g/dL)*0.990.98 to 1.000.05
 Serum neutrophils (×109/L)*1.020.92 to 1.120.74
 Serum CRP (mg/L)*1.011.0 to to 1.010.12
 Predisposing cardiac disease†1.810.31 to 10.450.51
 Intervention (12 months)‡0.300.07 to 1.340.12
 Native valve0.360.15 to 0.900.03
 Positive blood culture0.740.25 to 2.230.60
 Valvular abscess2.300.54 to 9.780.261.460.50 to 4.260.49
 Renal failure§4.011.01 to to 6.950.71
 Left-sided IE0.460.09 to 2.380.35
 Time to surgery1.131.06 to to 1.170.001
Medical patients
 Age (years)1.020.98 to 1.070.32
 Serum neutrophils (×109/L)*1.080.90 to 1.311.211.04 to 1.410.02
 Positive blood culture0.110.02 to 0.640.440.11 to 1.730.24
 Acute stroke2.320.35 to 15.490.3812.303.04 to 49.72<0.0001
 Duration of inpatient stay1.000.99 to 1.010.89
 ET0.240.07 to 0.870.03
  • All demographic, clinical and outcome data (apart from mortality) were first entered into a univariate model (online supplementary tables 1 and 2), and those found to be significant at a level of P<0.20 were then entered into a stepwise forward multivariate model.

  • *Admission values.

  • †Rheumatic disease, prosthetic valve or valve repair.

  • ‡Dental or surgical interventions within the past 12 months.

  • §Renal failure requiring renal replacement therapy.

  • CRP, C-reactive protein; eGFR, estimated glomerular filtration rate; ET, endocarditis team; EuroSCORE, European System for Cardiac Operative Risk Evaluation; IE, infective endocarditis.