Table 2

Baseline values of inflammatory markers; heart transplant recipients and healthy controls

Inflammatory biomarkers†HTx
(n=14)		Healthy controls
(n=5)		P value
General inflammation
 C reactive protein‡4.0
(0.5, 6.9)		1.7
(0.7, 4.7)		0.687
 sTNFr13.07
(2.68, 3.31)		2.18
(1.77, 2.62)		0.026*
Vascular inflammation
 von Willebrand factor§187
(92, 288)		111
(35, 146)		0.156
 VCAM489
(402, 616)		408
(390, 430)		0.115
Blood platelets
 Platelet-derived growth factor1.97
(1.40, 2.57)		2.87
(1.27, 4.16)		0.559
 sCD40L0.98
(0.66, 1.49)		1.59
(1.17, 1.88)		0.070
 DKK-12.08
(1.03, 4.28)		1.28
(0.58, 3.71)		0.440
Angiogenesis
 Vascular endothelial growth factor-10.19
(0.14, 0.28)		0.15
(0.14, 0.20)		0.298
 Angiopoietin-21.30
(1.08, 2.11)		1.47
(1.11, 1.98)		0.823
 Tie-215.9
(13.0, 17.7)		15.8
(13.4, 15.9)		0.817
 Endostatin162
(135, 200)		138
(114, 145)		0.165
Cardiokine/myokine
 GDF-151.14
(0.61, 1.41)		0.36
(0.32, 0.83)		0.019*
 ST217.5
(15.2, 26.9)		22.4
(17.0, 33.1)		0.247
 SPARC306
(127, 482)		212
(98, 909)		0.823

  • ↵*P value ≤0.05 between groups.

  • †All variables are presented as median with (1st quartile, 3rd quartile) and measured in ng/mL serum if not otherwise stated. ‡Measured as μg/mL.

  • §Measured as per cent of pool.

  • DKK-1, Dickkopf-related protein 1; GDF-15, growth differentiation factor-15; HTx, heart transplant recipients; sCD40L, soluble CD40 ligand; SPARC, secreted protein acidic and rich in cysteine; ST2, interleukin 1 receptor-like 1; sTNFr1, soluble tumour necrosis factor receptor 1; Tie-2, tyrosine kinase with immunoglobulin-like and EGF-like domains 2; VCAM, vascular cell adhesion molecule.