Table 2

Unadjusted outcomes by P2Y₁₂ inhibitor

Outcome	Prasugrel or ticagrelor n=1135	Clopidogrel n=784	p Value	Interaction p Value*
Acute stent thrombosis (≤24 hour)†	8/1035 (0.8)	5/1069 (0.5)	0.37‡	0.74
30-day outcomes§
Death or major bleeding	63 (5.6)	47 (6.0)	0.68	0.47
Death, reinfarction or major bleeding	77 (6.8)	56 (7.1)	0.76	0.74
Death	15 (1.3)	21 (2.7)	0.03	0.69
Cardiac death	14 (1.2)	18 (2.3)	0.07	0.87
Protocol bleeding
Major	53 (4.7)	30 (3.8)	0.37	0.90
Minor	88 (7.8)	43 (5.5)	0.05	0.93
Major or minor	141 (12.4)	73 (9.3)	0.03	0.88
TIMI bleeding
Major	19 (1.7)	15 (1.9)	0.70	0.97
Minor	122 (10.7)	56 (7.1)	0.007	0.93
Reinfarction	15 (1.3)	11 (1.4)	0.88	0.39
Stent thrombosis (definite)	13 (1.1)	8 (1.0)	0.80	0.11
Subacute (>24 hours to 30 days)	4 (0.4)	5 (0.6)	0.50‡	0.33
MACE§	44 (3.9)	43 (5.5)	0.10	0.86
NACE§	90 (7.9)	66 (8.4)	0.70	0.82

Data are presented as n (%) or n/N (%).
*Interaction p value for the interaction between choice of P2Y₁₂ inhibitor and effect of bivalirudin versus heparin.
†According to P2Y₁₂ loading dose.
‡p Value calculated using Fisher’s exact test. All other p values calculated using the χ² test.
§According to P2Y₁₂ maintenance dose.
MACE, major adverse cardiovascular events (death, reinfarction, ischaemia-driven revascularisation or stroke); NACE, net adverse clinical events (death, reinfarction, ischaemia-driven revascularisation, stroke or major bleeding); TIMI, Thrombolysis In Myocardial Infarction.