Ultrasound and ECG measures comparing cardiac arrest group with survivors
| Measure | Sudden death/cardiac arrest (n=32 for ECG measures, 27 for echocardiography) | National survivors (n=100) | p Value Mann-Whitney | ||
| Median | IQR | Median | IQR | ||
| Age at diagnosis (year) | 8.6 | 5.4–14.0 | 8.3 | 0.7–14.3 | n.s. |
| Duration FU (year) | 7.0 | 3.0–16.0 | 9.1 | 6.0–15.9 | n.s. |
| IVS diagnosis (cm) | 2.26 | 1.50–2.80 | 1.20 | 0.96–1.75 | p=0.000005 |
| IVS at last FU (cm) | 2.59 | 1.90–2.95 | 1.40 | 1.09–1.92 | p<0.0000001 |
| Maximum WT Z-score at diagnosis | 5.83 | 4.74–7.03 | 3.59 | 2.82–4.84 | p=0.00027 |
| Maximum WT Z-score at last FU | 6.07 | 5.33–7.66 | 3.55 | 2.31–4.68 | p=0.0000002 |
| PLVW at diagnosis (cm) | 0.90 | 0.80–1.38 | 0.88 | 0.63–1.10 | p=0.053, n.s. |
| PLVW at last FU (cm) | 1.30 | 1.00–1.64 | 0.93 | 0.78–1.10 | p=0.00018 |
| Sepcavr at diagnosis | 0.70 | 0.49–0.84 | 0.40 | 0.29–0.54 | p=0.000007 |
| Sepcavr at last FU | 0.73 | 0.49–1.00 | 0.36 | 0.26–0.50 | p=0.0000004 |
| LVcavr at diagnosis | 0.31 | 0.24–0.42 | 0.27 | 0.22–0.33 | n.s. |
| LVcavr at last FU | 0.31 | 0.25–0.47 | 0.21 | 0.20–0.26 | p=0.00002 |
| SEPPER at diagnosis | 261 | 193–306 | 143 | 120–189 | p<0.0000001 |
| SEPPER at last FU | 245 | 217–307 | 141 | 110–187 | p<0.0000001 |
| LVPER at diagnosis | 123 | 101–158 | 88 | 81–104 | p=0.0041 |
| LVPER at last FU | 127 | 108–167 | 88 | 81–104 | p=0.000004 |
| LA:Ao ratio early | 1.43 | 1.25–1.57 | 1.29 | 1.14–1.46 | p=0.054, n.s. |
| LA:Ao ratio late FU | 1.47 | 1.27–1.85 | 1.23 | 1.09–1.40 | p=0.0022 |
| LLQRSS diagnosis (mV) | 13.3 | 10.6–16.6 | 7.9 | 6.0–10.3 | p<0.0000001 |
| LLQRSS at last FU (mV) | 12.7 | 10.6–17.5 | 7.0 | 5.4–9.9 | p<0.0000001 |
| QRS duration at diagnosis (ms) | 90 | 80–97 | 80 | 70–89 | p=0.0044 |
| QRS duration at last FU (ms) | 100 | 90–118 | 89 | 81–108 | p=0.012 |
| 12-Lead product at diagnosis (mV.s) | 2.89 | 2.40–3.25 | 1.80 | 1.47–2.44 | p=0.000037 |
| 12-Lead product at last FU (mV.s) | 3.45 | 2.79–4.45 | 1.81 | 1.39–2.59 | p<0.0000001 |
| QTc at diagnosis (ms) | 448 | 419–475 | 410 | 389–423 | p=0.0000016 |
| QTc at last FU (ms) | 462 | 434–483 | 426 | 401–457 | p=0.00015 |
FU, follow-up; IVS, interventricular septum; La:Ao, left atrium-to-aorta diameter ratio; LLQRSS, limb-lead QRS amplitude sum18; LVcavr, posterior left ventricular-wall-to-cavity ratio; LVPER, left ventricular wall thickness in per cent of 95th centile for age18; PLVW, posterior left ventricular wall thickness; sepcavr, septum-to-cavity ratio; SEPPER, septal thickness in per cent of 95th centile for age18; 12-lead product, 12-lead amplitude × duration product17; WT, wall thickness.