Characteristics of patients with family history of sudden death
| Patients who died suddenly with FH of sudden death (n=8) | National cohort survivors with FH of sudden death (n=27) | ||||||
| Measure | Median | IQR | Range | Median | IQR | Range | p Value, Mann-Whitney U test |
| ECG risk score at diagnosis | 7 | 4–9 | 3–10 | 2 | 1–4 | 0–12 | 0.0059 |
| Latest ECG risk score | 8 | 7–10 | 6–11 | 1 | 0–5 | 0–10 | 0.0007 |
| MaxWT (cm) | 2.9 | 2.5–3.5 | 1.6–5.0 | 1.6 | 1.4–2.2 | 0.8–2.9 | 0.0011 |
| First maxWT Z-score | 6.00 | 4.70–7.33 | 3.93–7.80 | 3.52 | 2.63–4.79 | 2.11–7.69 | 0.0020 |
| Latest maxWT Z-score | 6.94 | 5.03–7.79 | 4.52–8.47 | 3.28 | 2.31–4.73 | 0.56–8.23 | 0.0010 |
| First SEPPER | 271 | 180–388 | 138–535 | 134 | 114–182 | 102–300 | 0.0023 |
| Latest SEPPER | 264 | 192–340 | 138–535 | 129 | 103–174 | 84–249 | 0.0011 |
| First LLQRSS (mV) | 13.3 | 11.3–20.5 | 5.9–25.8 | 8.0 | 6.5–10.1 | 4.1–23.4 | 0.0088 |
| Latest LLQRSS (mV) | 11.2 | 10.4–14.9 | 5.3–18.2 | 6.5 | 5.4–9.5 | 3.5–33.6 | 0.0125 |
| First sepcavr | 0.71 | 0.44–1.03 | 0.34–1.35 | 0.34 | 0.27–0.50 | 0.22–0.58 | 0.0056 |
| Latest sepcavr | 0.56 | 0.35–1.04 | 0.34–1.16 | 0.32 | 0.23–0.43 | 0.19–0.98 | 0.0093 |
| First QTc (ms) | 447 | 420–468 | 386–528 | 402 | 384–416 | 353–464 | 0.0059 |
| Latest QTc (ms) | 453 | 419–503 | 410–528 | 409 | 397–449 | 353–445 | 0.0048 |
FH, family history; LLQRSS, limb-lead QRS amplitude sum; MaxWT, maximum wall thickness; sepcavr, septum-to-cavity ratio; SEPPER, septum in % of 95th centile for age.