Univariate regression analysis | ||||
Parameter | B | SE | Exp (B) | Significance |
Age at diagnosis | 0.018 | 0.031 | 1.018 | p=0.568, n.s. |
Gender | 0.304 | 0.414 | 1.356 | p=0.462, n.s. |
Familial HCM | 0.125 | 0.401 | 1.133 | p=0.755, n.s. |
Family history of sudden death | 0.069 | 0.428 | 1.072 | p=0.871, n.s. |
History of cardiac syncope | −1.517 | 1.031 | 0.219 | p=0.234, n.s. |
First limb-lead QRS sum | 0.124 | 0.024 | 1.133 | p<0.001 |
First ECG risk score | 0.276 | 0.063 | 1.318 | p<0.001 |
First SEPPER (septum in % of 95th centile) | 0.013 | 0.002 | 1.013 | p<0.001 |
MaxWT Z-score at diagnosis | 0.591 | 0.143 | 1.806 | p<0.001 |
MaxWT (cm) at diagnosis | 0.773 | 0.195 | 2.166 | p<0.001 |
Left ventricular outflow tract obstruction at rest (>20 mm Hg) | 0.252 | 0.097 | 1.287 | p=0.009 |
First left atrium:aortic ratio | 0.021 | 0.007 | 1.021 | p=0.001 |
Pathological blood pressure rise on exercise | 0.601 | 0.623 | 1.823 | p=0.335, n.s. |
Ventricular tachycardia on Holter | 1.727 | 0.553 | 5.624 | p=0.002 |
Beta-blocker therapy | −1.314 | 0.414 | 0.269 | p=0.001 |
Early beta-blocker dose mg/kg | −0.262 | 0.105 | 0.770 | p=0.012 |
Beta-blocker+disopyramide | −1.595 | 0.619 | 0.203 | p=0.010 |
Calcium-blocker therapy | −0.073 | 0.555 | 0.930 | p=0.896, n.s. |
Amiodarone therapy | −0.078 | 0.752 | 1.081 | p=0.918, n.s. |
Myectomy | 0.084 | 0.507 | 1.088 | p=0.868, n.s. |
HCM, hypertrophic cardiomyopathy; maxWT, maximum wall thickness; SD/CA, sudden death/cardiac arrest; SEPPER, septum in % of 95th centile for age.