Table 1

Summary of treatment-emergent adverse events. Multiple adverse events for each subject are counted once within each unique category

SystemAdverse eventNumber of subjects with events (percentage)
Placebo (n=14)SRT2104 (n=15)
Immune systemAny event1 (7%)0
Seasonal allergy1 (7%)0
VascularAny event02 (13%)
Flushing02 (13%)
GeneralAny event2 (14%)3 (20%)
Fatigue1 (7%)1 (7%)
Flu-like illness01 (7%)
Asthenia1 (7%)0
Malaise01(%)
InfectionsAny event3 (21%)1 (7%)
Nasopharyngitis3 (21%)0
Upper respiratory tract infection01 (7%)
Renal and urinary disordersAny event1 (7%)0
Dysuria1 (7%)0
Any event-11 (79%)14 (93%)
Injury, poisoning and procedural complicationsAny event3 (21%)1 (7%)
Contusion1 (7%)0
Muscle strain1 (7%)0
Nail injury01 (7%)
Postprocedure discomfort1 (7%)0
NeurologicalAny event1 (7%)7 (47%)
Headache1 (7%)5 (33%)
Paraesthesia01 (7%)
Lethargy01 (7%)
GastrointestinalAny event4 (29%)8 (53%)
Diarrhoea2 (14%)4 (27%)
Nausea1 (7%)2 (13%)
Upper abdominal pain01 (7%)
Dyspepsia02 (13%)
Abdominal discomfort01 (7%)
Constipation1 (7%)0
Frequent bowel motions01 (7%)
Immune systemAny event1 (7%)0
Seasonal allergy1 (7%)0
VascularAny event02 (13%)
Flushing02 (13%)
GeneralAny event2 (14%)3 (20%)
Fatigue1 (7%)1 (7%)
Flu-like illness01 (7%)
Asthenia1 (7%)0
Malaise01(%)
InfectionsAny event3 (21%)1 (7%)
Nasopharyngitis3 (21%)0
Upper respiratory tract infection01 (7%)
Renal and urinary disordersAny event1 (7%)0
Dysuria1 (7%)0