Clinical characteristics and echocardiographic findings in 80 healthy individuals, 100 HCM LVH− patients and 180 HCM LVH+ patients
| Healthy individuals (n=80) | HCM LVH− patients (n=100) | HCM LVH+ patients (n=180) | p Value | |
| Age (years) | 54±15 | 36±15* | 53±17 | <0.001 |
| Women, n (%) | 45 (56) | 61 (61) | 75 (42)*† | <0.01 |
| BMI (kg/m2) | 24±3 | 24±4 | 27±4*† | <0.001 |
| BSA (m2) | 1.9±0.2 | 1.8±0.2 | 1.9±0.2† | <0.001 |
| Heart rate (bpm) | 62±10 | 68±14* | 64±11† | 0.01 |
| NYHA class (1–4) | 1.0±0.1 | 1.0±0.2 | 2.0±0.9*† | <0.001 |
| Systolic BP (mm Hg) | 124±11 | 127±18 | 131±12 | 0.27 |
| Diastolic BP (mm Hg) | 71±11 | 76±10 | 79±13 | 0.09 |
| Echocardiography | ||||
| MWT (mm) | 9±1 | 8±1 | 19±4*† | <0.001 |
| Peak LVOT gradient (mm Hg) | 4±1 | 5±2 | 31±4*† | <0.001 |
| LVEDD (mm) | 51±5 | 49±4* | 47±6*† | <0.001 |
| LVESD (mm) | 33±5 | 31±4* | 28±6*† | <0.001 |
| IVSd (mm) | 8±2 | 8±2 | 16±4*† | <0.001 |
| LVPWd | 8±2 | 8±3 | 10±3*† | <0.001 |
| LV mass/BSA (g/m2) | 73±22 | 71±15 | 132±45*† | <0.001 |
Values are represented as mean±SD.
p values are based on ANOVA and χ2 test.
*p<0.05 compared with healthy individuals.
†p<0.05 compared with HCM LVH− patients by Bonferroni post hoc correction.
ANOVA, analysis of variance; BMI, body mass index; BP, blood pressure; BPM, beats per minute; BSA, body surface area; HCM, hypertrophic cardiomyopathy; HCM LVH−, HCM patients without increased wall thickness; HCM LVH+, HCM patients with increased wall thickness; MWT, maximal wall thickness; NYHA class, New York Heart Association functional classification; LV, Left ventricular; LVEDD, left ventricular end-diastolic diameter; LVESD, left ventricular end-systolic diameter; LVH, left ventricular hypertrophy; LVOT, left ventricle outflow tract; LVPWd, left ventricular posterior wall diameter; IVSd, interventricular septum diameter.