LV volumes, EF and diastolic parameters evaluated by echocardiography in 80 healthy individuals, 100 HCM LVH− patients and 180 HCM LVH+ patients
| Healthy individuals (n=80) | HCM LVH− patients (n=100) | HCM LVH+ patients (n=180) | p Value | |
| EDV/BSA (mL/m2) | 57±14 | 49±13* | 41±14*† | <0.001 |
| ESV/BSA (mL/m2) | 23±9 | 19±6* | 16±7*† | <0.001 |
| EF (%) | 61±6 | 60±5 | 61±7 | 0.43 |
| GLS (%) | −22.3±3.7 | −21.3±2.4 | −16.4±3.7*† | <0.001 |
| E (m/s) | 0.7±0.2 | 0.8±0.2 | 0.8±0.8 | 0.24 |
| E/A ratio | 1.4±0.5 | 1.6±0.6 | 1.3±0.7† | 0.04 |
| Deceleration time (ms) | 195±48 | 175±30 | 217±74*† | <0.001 |
| E/e′ | 6.4±2.1 | 7.0±2.2 | 14.9±8.3*† | <0.001 |
| e′ (m/s) | 0.12±0.03 | 0.06±0.03* | 0.11±0.04*† | <0.001 |
| LA area (cm2) | 17.0±4.1 | 16.3±4.5 | 24.9±11.3*† | <0.001 |
The values are represented as mean±SD.
p values are based on Student’s t-test.
*p<0.05 compared with healthy individuals.
†p<0.05 compared with HCM LVH− patients.
A, atrial transmitral filling velocity; BSA, body surface area; e′, early diastolic myocardial velocity; E, early transmitral flow velocity; EDV, end-diastolic volume; EF, ejection fraction; ESV, end-systolic volume; GLS, global longitudinal strain; HCM, hypertrophic cardiomyopathy; HCM LVH−, HCM patients without increased wall thickness; HCM LVH+, HCM patients with increased wall thickness; LA, left atrium; LV, left ventricle; LVH, left ventricular hypertrophy.