Comparisons of clinical features of patients by tertiles of FIB4 index (n=1058)
| First tertile FIB4 <1.72 (n=353) | Second tertile 1.72< FIB4<3.01 (n=353) | Third tertile 3.01< FIB4 (n=352) | p Value | |
| Age (years) | 56.1±15.0 | 70.6±10.6** | 75.4±9.4**†† | <0.001 |
| Male gender (n, %) | 230 (65.2) | 213 (60.3) | 200 (56.8) | 0.075 |
| Body mass index (kg/cm2) | 24.4±4.4 | 23.0±4.3** | 22.7±3.8**†† | <0.001 |
| Systolic BP (mm Hg) | 125.8±29.5 | 129.2±33.4 | 129.6±33.0 | 0.222 |
| Diastolic BP (mm Hg) | 73.0±20.6 | 72.9±20.0 | 72.1±20.5 | 0.820 |
| Heart rate (bpm) | 82.0±23.5 | 79.8±25.0 | 80.7±24.7 | 0.490 |
| NYHA class III or IV | 4 (1.1) | 9 (2.5) | 18 (5.1) | 0.006 |
| Ischaemic aetiology (n, %) | 79 (22.4) | 94 (26.6) | 104 (29.5) | 0.094 |
| Reduced LVEF (n, %) | 197 (55.8) | 179 (50.7) | 192 (54.5) | 0.367 |
| Comorbidity | ||||
| Hypertension (n, %) | 256 (72.5) | 295 (83.6) | 280 (79.5) | 0.001 |
| Diabetes (n, %) | 134 (38.0) | 151 (42.8) | 147 (41.8) | 0.390 |
| Dyslipidaemia (n, %) | 290 (82.2) | 280 (79.3) | 258 (73.3) | 0.014 |
| Atrial fibrillation (n, %) | 98 (27.8) | 137 (38.8) | 175 (49.7) | <0.001 |
| CKD (n, %) | 149 (42.2) | 207 (58.6) | 258 (73.3) | <0.001 |
| Anaemia (n, %) | 155 (43.9) | 196 (55.5) | 238 (67.6) | <0.001 |
| Medications | ||||
| RAS inhibitors (n, %) | 262 (74.2) | 274 (77.6) | 267 (75.9) | 0.572 |
| β-blockers (n, %) | 278 (78.8) | 288 (81.6) | 271 (77.0) | 0.317 |
| Diuretics (n, %) | 217 (61.5) | 249 (70.5) | 263 (74.7) | 0.001 |
| Inotropic agents (n, %) | 25 (7.1) | 34 (9.6) | 57 (16.2) | <0.001 |
Data are presented as median (IQR).
**p<0.01 versus 1 tertile.
††p<0.01 versus second tertile.
BP, blood pressure; NYHA, New York Heart Association; LVEF, left ventricular ejection fraction; CKD, chronic kidney disease; RAS, rennin-angiotensin-aldosterone system.