The frequencies and incidence ages of clinical LMNA mutation or cardiomyopathy manifestations
| All LMNA mutation carriers, n=27 | LMNA mutation carriers with DCM, that is, LMNA-DCM subgroup, n=12 | DCM controls, n=78 | |||
|---|---|---|---|---|---|
| N (%) | p Value* | N (%) | p Value* | N (%) | |
| AF | 15 (55.6) | NS | 11 (91.7) | 0.007 | 39 (50.0) |
| NSVT | 21 (77.8) | 11 (91.7) | |||
| Pacemaker (any, including ICDs) | 16 (59.3) | NS | 10 (83.3) | 0.020 | 37 (47.4) |
| ICD | 9 (33.3) | NS | 6 (50.0) | NS | 26 (33.3) |
| Thrombosis | 4 (14.8) | NS | 4 (33.3) | NS | 12 (15.4) |
| Major end point | 7 (25.9) | 0.039 | 7 (58.3) | NS | 38 (48.7) |
| Males | 13 (48.1) | 0.026 | 6 (50.0) | NS | 56 (71.8) |
| Mean (SD) | Mean (SD) | Mean (SD) | |||
| Age at DCM diagnosis | 48.7 (10.7) | NS | 48.2 (10.4) | NS | 47.4 (12.2) |
| Age at AF | 46.9 (10.9) | 0.003 | 47.9 (10.7) | 0.014 | 56.9 (10.1) |
| Age at NSVT | 45.6 (11.8) | 49.1 (10.1) | |||
| Age at PM | 49.1 (10.6) | NS | 49.6 (11.1) | NS | 55.4 (13.0) |
| Age at ICD | 48.5 (11.4) | NS | 52.0 (12.7) | NS | 53.0 (12.9) |
| Age at thrombosis | 52.6 (10.0) | NS | 52.6 (10.0) | NS | 54.8 (12.5) |
| Age at major end point | 51.0 (8.7) | NS | 51.0 (8.7) | NS | 59.0 (14.2) |
Comparisons of all the LMNA mutation carriers and those LMNA mutation carriers fulfilling the criteria for DCM to the DCM controls.
*Comparisons to all DCM controls.
AF, atrial fibrillation; DCM, dilated cardiomyopathy; ICD, implantable cardioverter-defibrillator; NS, not significant; NSVT, non-sustained ventricular tachycardia; PM, pacemaker.