TableĀ 1

The frequencies and incidence ages of clinical LMNA mutation or cardiomyopathy manifestations

All LMNA mutation carriers, n=27LMNA mutation carriers with DCM, that is, LMNA-DCM subgroup, n=12DCM controls, n=78
N (%)p Value*N (%)p Value*N (%)
AF15 (55.6)NS11 (91.7)0.00739 (50.0)
NSVT21 (77.8)11 (91.7)
Pacemaker (any, including ICDs)16 (59.3)NS10 (83.3)0.02037 (47.4)
ICD9 (33.3)NS6 (50.0)NS26 (33.3)
Thrombosis4 (14.8)NS4 (33.3)NS12 (15.4)
Major end point7 (25.9)0.0397 (58.3)NS38 (48.7)
Males13 (48.1)0.0266 (50.0)NS56 (71.8)
Mean (SD)Mean (SD)Mean (SD)
Age at DCM diagnosis48.7 (10.7)NS48.2 (10.4)NS47.4 (12.2)
Age at AF46.9 (10.9)0.00347.9 (10.7)0.01456.9 (10.1)
Age at NSVT45.6 (11.8)49.1 (10.1)
Age at PM49.1 (10.6)NS49.6 (11.1)NS55.4 (13.0)
Age at ICD48.5 (11.4)NS52.0 (12.7)NS53.0 (12.9)
Age at thrombosis52.6 (10.0)NS52.6 (10.0)NS54.8 (12.5)
Age at major end point51.0 (8.7)NS51.0 (8.7)NS59.0 (14.2)
  • Comparisons of all the LMNA mutation carriers and those LMNA mutation carriers fulfilling the criteria for DCM to the DCM controls.

  • *Comparisons to all DCM controls.

  • AF, atrial fibrillation; DCM, dilated cardiomyopathy; ICD, implantable cardioverter-defibrillator; NS, not significant; NSVT, non-sustained ventricular tachycardia; PM, pacemaker.